Evidence map›Paper›PMID 28791568›Full record

ArticleMolecular diversity2017

Synthesis and biological evaluation of glycosides containing triazene-chalcones.

Qiang Lei, Saiyang Zhang, Manli Liu, Jia Li, Xi Zhang, Yue Long

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qiang LeiCollege of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.
Saiyang ZhangSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.
Manli LiuCollege of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.
Jia LiCollege of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.
Xi ZhangCollege of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.
Yue LongCollege of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, People's Republic of China. longyue@zzu.edu.cn.
Zhengzhou University · CN

Funding

Basic Research Development Program of Henan Province 022463001Science and Technology Planning Project of Henan Province 0624420031the Natural Science Foundation of China J1210060
6 · The paper itself

Abstract

By combining triazenes with chalcones, we designed and synthesized 12 novel glycosides. The antiproliferative activity of all products was screened using an MTT assay against MGC803 cells and PC-3 cells. Compound [Formula: see text] displayed more potent antiproliferative activity than dacarbazine. Furthermore, we explored the preliminary structure activity relationship of all target compounds. The derivatives in this work might serve as bioactive fragments and lead compounds for developing more potent cytotoxic agents.

Indexed as

Antineoplastic AgentsCell Line, TumorCell ProliferationChalconesChemistry Techniques, SyntheticGlycosidesHumansModels, MolecularMolecular ConformationStructure-Activity RelationshipTriazenesAntineoplastic AgentsChalconesGlycosidesTriazenesAntiproliferative activityChalconeGlycosidesSynthesisTriazene

Identifiers

PMID28791568
OpenAlexW2742883371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.