Evidence map›Paper›PMID 28791289›Full record

ReviewFrontiers in medicine2017

Transcription Factors in Eosinophil Development and As Therapeutic Targets.

Patricia C Fulkerson

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 52 citations in OpenAlex.

  1. Tissue adaptation of eosinophils.Journal of leukocyte biology · 2026
    Review
  2. Article
  3. Myeloid cells in chronic liver inflammation.Cellular & molecular immunology · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Role of Innate Immunity in Allergic Contact Dermatitis: An Update.International journal of molecular sciences · 2023
    Review
  9. Emerging functions of tissue-resident eosinophils.The Journal of experimental medicine · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Emerging Evidence for Pleiotropism of Eosinophils.International journal of molecular sciences · 2021
    Review
  16. Review
  17. Can Eosinophils Prevent Lung Injury? Ask PHIL.American journal of respiratory cell and molecular biology · 2021
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Patricia C FulkersonDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Cincinnati Children's Hospital Medical Center · US

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
Role of Aiolos in eosinophilic AsthmaR01AI130033 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI ROTHENBERG, MARC E. · 2017 to 2021
$2.4M
NIAID NIH HHS R01 AI130033NIDDK NIH HHS P30 DK078392
6 · The paper itself

Abstract

Dynamic gene expression is a major regulatory mechanism that directs hematopoietic cell fate and differentiation, including eosinophil lineage commitment and eosinophil differentiation. Though GATA-1 is well established as a critical transcription factor (TF) for eosinophil development, delineating the transcriptional networks that regulate eosinophil development at homeostasis and in inflammatory states is not complete. Yet, recent advances in molecular experimental tools using purified eosinophil developmental stages have led to identifying new regulators of gene expression during eosinophil development. Herein, recent studies that have provided new insight into the mechanisms of gene regulation during eosinophil lineage commitment and eosinophil differentiation are reviewed. A model is described wherein distinct classes of TFs work together

Indexed as

eosinophil developmenteosinophil lineage commitmenteosinophilopoiesishematopoiesistranscriptional regulation

Identifiers

PMID28791289
PMCPMC5522844
OpenAlexW2738184804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.