ArticlePeerJ2017
Simulated bacterial infection disrupts the circadian fluctuation of immune cells in wrinkle-lipped bats (
Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Handling Stress and Sample Storage Are Associated with Weaker Complement-Mediated Bactericidal Ability in Birds but Not Bats.Physiological and biochemical zoology : PBZPooled it
- Article
- Bat behavioral immune responses in social contexts: current knowledge and future directions.Frontiers in immunology · 2023Review
- Sick bats stay home alone: fruit bats practice social distancing when faced with an immunological challenge.Annals of the New York Academy of Sciences · 2021Article
- Disentangling interactions among mercury, immunity and infection in a Neotropical bat community.The Journal of applied ecology · 2021Article
- The immune response of bats differs between pre-migration and migration seasons.Scientific reports · 2020Article
- Immune response of hibernating European bats to a fungal challenge.Biology open · 2019Article
- Livestock abundance predicts vampire bat demography, immune profiles and bacterial infection risk.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Going to Bat(s) for Studies of Disease Tolerance.Frontiers in immunology · 2018Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeukocyte concentrations follow a circadian pattern in mammals, with elevated values at times of potential contact with pathogens and parasites. We hypothesized that this pattern is disturbed after an immune challenge.
methodsIn Thailand, we captured wrinkle-lipped bats (
resultsIn experimental animals, we observed an increase in total leukocyte and neutrophil numbers of 17% and 95%, respectively. In control animals, concentrations of leukocytes decreased by 44% and those of neutrophils remained constant. Experimental treatment had no effect on lymphocytes, yet changes in eosinophil numbers were explained by sex. Eosinophils decreased by 66% in females and by 62% in males. Basophils and monocytes were rarest among all observed cell types and analysis was either impossible because of low numbers or yielded no significant effects, respectively. DISCUSSION: Our findings show that a simulated bacterial infection triggered a neutrophil-associated immune response in wrinkle-lipped bats, indicating a disruption of the diurnal fluctuation of immune cells. Our study suggests that bats exhibit circadian rhythms in immune cell counts. The magnitude of these fluctuations may vary across species according to specific-specific infection risks associated with colony sizes or specific roosting habits.
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