Evidence map›Paper›PMID 28791090›Full record

ArticleChemical science2015

Spatial regulation of a common precursor from two distinct genes generates metabolite diversity.

Chun-Jun Guo, Wei-Wen Sun, Kenneth S Bruno, Berl R Oakley, Nancy P Keller, Clay C C Wang

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  3. Exploring the Anti-Alzheimer's Disease Potential ofJournal of fungi (Basel, Switzerland) · 2025
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  8. Subcellular localization of fungal specialized metabolites.Fungal biology and biotechnology · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Chun-Jun GuoDepartment of Pharmacology and Pharmaceutical Sciences , School of Pharmacy , University of Southern California , Los Angeles , CA 90089 , USA . Email: clayw@usc.edu.
Wei-Wen SunDepartment of Pharmacology and Pharmaceutical Sciences , School of Pharmacy , University of Southern California , Los Angeles , CA 90089 , USA . Email: clayw@usc.edu.
Kenneth S BrunoChemical and Biological Process Development Group , Energy and Environment Directorate , Pacific Northwest National Laboratory , Richland , WA 99352 , USA.
Berl R OakleyDepartment of Molecular Biosciences , University of Kansas , Lawrence , KS 66045 , USA.
Nancy P KellerDepartment of Medical Microbiology and Immunology , University of Wisconsin-Madison , Madison , WI 53706 , USA.
Clay C C WangDepartment of Pharmacology and Pharmaceutical Sciences , School of Pharmacy , University of Southern California , Los Angeles , CA 90089 , USA . Email: clayw@usc.edu.
Southern California University for Professional Studies · USLos Angeles City College · USMadison Group (United States) · USPacific Northwest National Laboratory · USUniversity of Kansas · US

Funding

Molecular Genetic Mining of the Aspergillus Nidulans Secondary MetabolomeP01GM084077 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OAKLEY, BERL RAY · 2008 to 2012
$5.4M
NIGMS NIH HHS P01 GM084077
6 · The paper itself

Abstract

In secondary metabolite biosynthesis, core synthetic genes such as polyketide synthase genes usually encode proteins that generate various backbone precursors. These precursors are modified by other tailoring enzymes to yield a large variety of different secondary metabolites. The number of core synthesis genes in a given species correlates, therefore, with the number of types of secondary metabolites the organism can produce. In our study, heterologous expression of all the

Identifiers

PMID28791090
PMCPMC5523082
OpenAlexW1963299105

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.