Evidence map›Paper›PMID 28790989›Full record

ArticleFrontiers in microbiology2017

A Proposal for a Structural Model of the Feline Calicivirus Protease Bound to the Substrate Peptide under Physiological Conditions.

Masaru Yokoyama, Tomoichiro Oka, Hirotaka Takagi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yukinobu Tohya, Hironori Sato

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Masaru YokoyamaPathogen Genomics Center, National Institute of Infectious DiseasesTokyo, Japan.
Tomoichiro OkaDepartment of Virology II, National Institute of Infectious DiseasesTokyo, Japan.
Hirotaka TakagiDivision of Biosafety Control and Research, National Institute of Infectious DiseasesTokyo, Japan.
Hirotatsu KojimaDrug Discovery Initiative, The University of TokyoTokyo, Japan.
Takayoshi OkabeDrug Discovery Initiative, The University of TokyoTokyo, Japan.
Tetsuo NaganoDrug Discovery Initiative, The University of TokyoTokyo, Japan.
Yukinobu TohyaDepartment of Veterinary Medicine, Nihon UniversityFujisawa, Japan.
Hironori SatoPathogen Genomics Center, National Institute of Infectious DiseasesTokyo, Japan.
National Institute of Infectious Diseases · JPThe University of Tokyo · JPNihon University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feline calicivirus (FCV) protease functions to cleave viral precursor proteins during productive infection. Previous studies have mapped a protease-coding region and six cleavage sites in viral precursor proteins. However, how the FCV protease interacts with its substrates remains unknown. To gain insights into the interactions, we constructed a molecular model of the FCV protease bound with the octapeptide containing a cleavage site of the capsid precursor protein by homology modeling and docking simulation. The complex model was used to screen for the substrate mimic from a chemical library by pharmacophore-based

Indexed as

3-D pharmacophoreBRET technologyfeline calicivirusin silico screeningMD simulationprotease

Identifiers

PMID28790989
PMCPMC5524728
OpenAlexW2738092767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.