Evidence map›Paper›PMID 28790975›Full record

ReviewFrontiers in endocrinology2017

Rodent Models of Non-classical Progesterone Action Regulating Ovulation.

Melinda A Mittelman-Smith, Lauren M Rudolph, Margaret A Mohr, Paul E Micevych

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Grid1 regulates the onset of puberty in female rats.The Journal of veterinary medical science · 2024
    Article
  3. AstrocyticCannabis and cannabinoid research · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Steroids and TRP Channels: A Close Relationship.International journal of molecular sciences · 2020
    Review
  13. De Novo Synthesized Estradiol: A Role in Modulating the Cerebellar Function.International journal of molecular sciences · 2020
    Review
  14. Review
  15. Uterine GαFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Melinda A Mittelman-SmithDepartment of Neurobiology, David Geffen School of Medicine at UCLA, The Laboratory of Neuroendocrinology, Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States.
Lauren M RudolphDepartment of Neurobiology, David Geffen School of Medicine at UCLA, The Laboratory of Neuroendocrinology, Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States.
Margaret A MohrDepartment of Neurobiology, David Geffen School of Medicine at UCLA, The Laboratory of Neuroendocrinology, Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States.
Paul E MicevychDepartment of Neurobiology, David Geffen School of Medicine at UCLA, The Laboratory of Neuroendocrinology, Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · US

Funding

Physiology of Hypothalamic Neurosteroidal ProgesteroneR01HD042635 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MICEVYCH, PAUL E · 2003 to 2019
$4.8M
Neuroendocrinology, Sex Differences, and ReproductionT32HD007228 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P · 1985 to 2015
$3.9M
NICHD NIH HHS R01 HD042635NICHD NIH HHS T32 HD007228
6 · The paper itself

Abstract

It is becoming clear that steroid hormones act not only by binding to nuclear receptors that associate with specific response elements in the nucleus but also by binding to receptors on the cell membrane. In this newly discovered manner, steroid hormones can initiate intracellular signaling cascades which elicit rapid effects such as release of internal calcium stores and activation of kinases. We have learned much about the translocation and signaling of steroid hormone receptors from investigations into estrogen receptor α, which can be trafficked to, and signal from, the cell membrane. It is now clear that progesterone (P4) can also elicit effects that cannot be exclusively explained by transcriptional changes. Similar to E2 and its receptors, P4 can initiate signaling at the cell membrane, both through progesterone receptor and via a host of newly discovered membrane receptors (e.g., membrane progesterone receptors, progesterone receptor membrane components). This review discusses the parallels between neurotransmitter-like E2 action and the more recently investigated non-classical P4 signaling, in the context of reproductive behaviors in the rodent.

Indexed as

estrogenhypothalamuskisspeptinlordosisluteinizing hormoneovulationprogesteronereproduction

Identifiers

PMID28790975
PMCPMC5522857
OpenAlexW2737691306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.