Evidence map›Paper›PMID 28790974›Full record

ArticleFrontiers in neurology2017

Selective Inhibition of Janus Kinase 3 Has No Impact on Infarct Size or Neurobehavioral Outcomes in Permanent Ischemic Stroke in Mice.

Kelly M DeMars, Sean C Pacheco, Changjun Yang, David M Siwarski, Eduardo Candelario-Jalil

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kelly M DeMarsDepartment of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, United States.
Sean C PachecoDepartment of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, United States.
Changjun YangDepartment of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, United States.
David M SiwarskiDepartment of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, United States.
Eduardo Candelario-JalilDepartment of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, United States.
University of Florida · US

Funding

Cyclooxygenase-2 Regulation of Blood-Brain Barrier Opening in Ischemic StrokeR01NS065849 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CANDELARIO-JALIL, EDUARDO JESUS · 2011 to 2015
$1.5M
NINDS NIH HHS R01 NS065849
6 · The paper itself

Abstract

Janus kinase 3 (JAK3) is associated with the common gamma chain of several interleukin (IL) receptors essential to inflammatory signaling. To study the potential role of JAK3 in stroke-induced neuroinflammation, we subjected mice to permanent middle cerebral artery occlusion and investigated the effects of JAK3 inhibition with decernotinib (VX-509) on infarct size, behavior, and levels of several inflammatory mediators. Results from our double immunofluorescence staining showed JAK3 expression on neurons, endothelial cells, and microglia/macrophages in the ischemic mouse brain (

Indexed as

decernotinib (VX-509)ischemic strokeJanus kinase 3middle cerebral artery occlusionneuroinflammation

Identifiers

PMID28790974
PMCPMC5524742
OpenAlexW2738723191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.