ArticleFrontiers in neurology2017
Malignant Cerebellar Edema Subsequent to Accidental Prescription Opioid Intoxication in Children.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Dextromethorphan-Associated Neurotoxicity with Cerebellar Edema Syndrome in Young Children: Neuroimaging Features.AJNR. American journal of neuroradiology · 2025Article
- Opioid neurotoxicity: A case series and review from members of the Child Neurology Society Neurocritical Care Special Interest Group.Annals of the Child Neurology Society · 2024Article
- Article
- Article
- Neuroimaging features of accidental fentanyl overdose in a toddler.BMJ case reports · 2024Article
- Pediatric Opioid‑Use‑Associated Neurotoxicity with Cerebellar Edema: A Case of POUNCE Syndrome Following Vein of Galen Aneurysm Treatment.Journal of the Belgian Society of Radiology · 2024Article
- Cerebellar, hippocampal, and basal nuclei transient edema with restricted diffusion (CHANTER) syndrome in the setting of opioid and phencyclidine use.Radiology case reports · 2023Article
- The molecular neurobiology and neuropathology of opioid use disorder.Current research in neurobiology · 2021Article
- Acute Cytotoxic Cerebellar Edema Subsequent to Fentanyl Patch Intoxication in an Infant.Case reports in critical care · 2021Article
- Lesson of the month: Oxycodone-induced leukoencephalopathy: a rare diagnosis.Clinical medicine (London, England) · 2020Article
- Review
- Malignant cerebellar edema in three-year-old girl following accidental opioid ingestion and fentanyl administration.The neuroradiology journal · 2019Article
- Methadone-induced Toxic Encephalopathy In Pediatric Patients: Two Case Reports.Journal of radiology case reports · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present two recent cases of toddlers who developed malignant cerebellar edema subsequent to accidental ingestion of prescription opioids. Both children presented acute neurological decline, hydrocephalus, and tonsillar herniation requiring emergent ventricular drain placement, suboccipital craniectomy, and partial cerebellectomy. Together with several other reports, these cases suggest the existence of an uncommon yet severe syndrome of acute opioid-induced malignant cerebellar edema. We hypothesize that the condition results from a combination of primary opioid receptor-mediated changes in neuronal metabolism that are exacerbated by secondary hypoxic insult. If recognized promptly, this syndrome can be treated with emergent neurosurgical intervention with good clinical outcomes. These cases also illustrate the unintended consequences and innocent victims of the spiraling prescription opioid epidemic, which will likely increase in prevalence. Recognition of this syndrome by clinicians is thus critical.
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