ReviewClinical ophthalmology (Auckland, N.Z.)2017
Intense pulsed light for evaporative dry eye disease.
Review in Clinical ophthalmology (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06392438 (Combination of 0.09% Cyclosporine and Intense Pulsed Light), which is not on this map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combination of 0.09% Cyclosporine and Intense Pulsed Light (IPL) Therapy for the Treatment of Dry Eye Disease in Symptomatic Contact Lens Wearers: a Sham-Controlled Randomized Clinical Trial
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Intense pulsed light for meibomian gland dysfunction: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Pooled it
- Intense pulsed light (IPL) therapy for the treatment of meibomian gland dysfunction.The Cochrane database of systematic reviews · 2020Pooled it
- Efficacy of intense pulsed light therapy combined with eyelid margin cleaning using a deep cleaning device in the treatment of meibomian gland dysfunction: a randomized controlled trial.International ophthalmology · 2025Trial
- A randomized controlled study evaluating outcomes of intense pulsed light and low-level light therapy for treating meibomian gland dysfunction and evaporative dry eye.Indian journal of ophthalmology · 2023Trial
- Multi-Frequency RF Combined with Intense Pulsed Light Improves Signs and Symptoms of Dry Eye Disease Due to Meibomian Gland Dysfunction.Clinical ophthalmology (Auckland, N.Z.) · 2023Trial
- Intense pulsed light improves signs and symptoms of dry eye disease due to meibomian gland dysfunction: A randomized controlled study.PloS one · 2022Trial
- Effects of intense pulsed light treatment on tear cytokines and clinical outcomes in meibomian gland dysfunction.PloS one · 2021Trial
- Trial
- Comparison of two intense pulsed light patterns for treating patients with meibomian gland dysfunction.International ophthalmology · 2020Trial
- Clinical characteristics and preliminary retrospective evidence of adjunctive efficacy of intense pulsed light therapy for Demodex-associated blepharokeratoconjunctivitis: a single-center study.Annals of medicine · 2026Article
- Intense pulsed light as a multi-target intervention paradigm for refractory ocular surface diseases: a review.Eye and vision (London, England) · 2026Review
- Home-based low-level light therapy using a commercial LED mask for dry eye disease.International ophthalmology · 2026Observational
- Characteristics of Patients with Refractory Meibomian Gland Dysfunction Unresponsive to Intense Pulsed Light Treatment Using a Vascular Filter.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Comparative Clinical Outcomes of Radiofrequency, Intense Pulsed Light, and Combined Therapy for Meibomian Gland Dysfunction-Related Dry Eye.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Therapeutic Outcomes of Combined Eyelid Hygiene, Intense Pulsed Light, and Meibomian Gland Expression in Meibomian Gland Dysfunction.Journal of clinical medicine · 2025Article
- Identification of tear lipid biomarkers in women with dry eye disease and the impact of intense pulsed light therapy: a case-control study.BMC ophthalmology · 2025Observational
- Network meta-analysis of different modalities of intense pulsed light therapy in the treatment of dry eye disease induced by meibomian gland dysfunction.Lasers in medical science · 2025Article
- Intense Pulsed Light Combined with Low Level Blue and Red Light Therapy forClinical ophthalmology (Auckland, N.Z.) · 2025Article
- How Eyelid Changes May Impact on Tears.Journal of clinical medicine · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a clear association between dry eye disease (DED) and skin inflammatory diseases occurring in close proximity to the eyelids, such as facial skin rosacea. Intense pulsed light (IPL) is widely accepted as a treatment for skin rosacea. A number of recent studies demonstrated that, in patients suffering from meibomian gland dysfunction (MGD), IPL therapy also reduces signs and symptoms of DED. Despite these encouraging results, in the context of DED and MGD, the mechanisms of action of IPL are not well understood. The purpose of this review was to raise the potential mechanisms of action and to discuss their plausibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.