Evidence map›Paper›PMID 28790434›Full record

ArticleScientific reports2017

Regulation of Osteoclast Differentiation by Myosin X.

Amy Tasca, Kristina Astleford, Ari Lederman, Eric D Jensen, Beth S Lee, Rajaram Gopalakrishnan, Kim C Mansky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Miro proteins and their role in mitochondrial transfer in cancer and beyond.Frontiers in cell and developmental biology · 2022
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Sodium alendronate loaded poly(l-lactide-Regenerative biomaterials · 2020
    Article
  16. Review
  17. Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amy TascaDepartment of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota, 55455, USA.
Kristina AstlefordDepartment of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, Minnesota, 55455, USA.
Ari LedermanDepartment of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota, 55455, USA.
Eric D JensenDepartment of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota, 55455, USA.
Beth S LeeDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, 43210, USA.
Rajaram GopalakrishnanDepartment of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota, 55455, USA.
Kim C ManskyDepartment of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, Minnesota, 55455, USA. kmansky@umn.edu.

Funding

Role of Twisted Gastrulation in OsteoclastogenesisR01AR056642 · NIAMS · UNIVERSITY OF MINNESOTA · PI GOPALAKRISHNAN, RAJARAM · 2010 to 2014
$1.6M
The role of MyosinX in BMPs promotion of SMAD 1/5 in osteoclast formation and funF32DE024679 · NIDCR · UNIVERSITY OF MINNESOTA · PI TASCA, AMY · 2014 to 2015
$138k
NIAMS NIH HHS R01 AR056642NIDCR NIH HHS F32 DE024679
6 · The paper itself

Abstract

Osteoclasts begin as mononuclear cells that fuse to form multinuclear cells able to resorb bone. The mechanisms that regulate all the steps of osteoclast differentiation are not entirely known. MYO10, an unconventional myosin, has previously been shown in mature osteoclasts to play a role in attachment and podosome positioning. We determined that MYO10 is also expressed early during osteoclast differentiation. Loss of MYO10 expression in osteoclast precursors inhibits the ability of mononuclear osteoclasts to fuse into multinuclear osteoclasts. Expression of Nfatc1, Dc-stamp, Ctsk, and β

Indexed as

AnimalsBone ResorptionCathepsin KCell DifferentiationCell FusionCell MovementFemurGene Expression RegulationHumansIntegrin beta3Membrane ProteinsMiceMice, Inbred C57BLMyosinsNerve Tissue ProteinsNFATC Transcription FactorsCathepsin KCtsk protein, mouseDC-STAMP protein, mouseIntegrin beta3Membrane ProteinsMyo10 protein, mouseMyosinsNerve Tissue ProteinsNfatc1 protein, mouseNFATC Transcription FactorsSmad Proteins

Identifiers

PMID28790434
PMCPMC5548914

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.