ArticleScientific reports2017
Spiral Form of the Human Cochlea Results from Spatial Constraints.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Biodistribution and transport of intratympanically administered drugs in the inner ear using a porcine ex-vivo chamber model.Materials & design · 2026Article
- The cochlear morphometry compendium: High-resolution synchrotron measurements and normative reference values.Journal of anatomy · 2026Article
- Article
- Interplay between evolutionary history, morphological constraints and functional adaptations in the primate cochlea.Royal Society open science · 2025Article
- Automated segmentation of clinical CT scans of the cochlea and analysis of the cochlea's vertical profile.Heliyon · 2024Article
- Landmark-based registration of a cochlear model to a human cochlea using conventional CT scans.Scientific reports · 2024Article
- Simultaneous analysis of shape and internal structure of a curved Hibiscus cannabinus pulvinus: X-ray microtomography and semi-automated quantification.Journal of plant research · 2024Article
- Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs.Frontiers in pharmacology · 2024Article
- Models of Cochlea Used in Cochlear Implant Research: A Review.Annals of biomedical engineering · 2023Review
- Development and In-Silico and Ex-Vivo Validation of a Software for a Semi-Automated Segmentation of the Round Window Niche to Design a Patient Specific Implant to Treat Inner Ear Disorders.Journal of imaging · 2023Article
- Anodic Polarity Minimizes Facial Nerve Stimulation as a Side Effect of Cochlear Implantation.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Anatomical Variations of the Human Cochlea Using an Image Analysis Tool.Journal of clinical medicine · 2023Article
- Optimization of pharmacological interventions in the guinea pig animal model-a new approach to calculate the perilymph volume of the scala tympani.Frontiers in neuroscience · 2023Article
- Article
- A Web-Based Automated Image Processing Research Platform for Cochlear Implantation-Related Studies.Journal of clinical medicine · 2022Article
- Variations in microanatomy of the human modiolus require individualized cochlear implantation.Scientific reports · 2022Article
- Is Characteristic Frequency Limiting Real-Time Electrocochleography During Cochlear Implantation?Frontiers in neuroscience · 2022Article
- Review
- 3D printed biomimetic cochleae and machine learning co-modelling provides clinical informatics for cochlear implant patients.Nature communications · 2021Article
- Cochlear shape distinguishes southern African early hominin taxa with unique auditory ecologies.Scientific reports · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human inner ear has an intricate spiral shape often compared to shells of mollusks, particularly to the nautilus shell. It has inspired many functional hearing theories. The reasons for this complex geometry remain unresolved. We digitized 138 human cochleae at microscopic resolution and observed an astonishing interindividual variability in the shape. A 3D analytical cochlear model was developed that fits the analyzed data with high precision. The cochlear geometry neither matched a proposed function, namely sound focusing similar to a whispering gallery, nor did it have the form of a nautilus. Instead, the innate cochlear blueprint and its actual ontogenetic variants were determined by spatial constraints and resulted from an efficient packing of the cochlear duct within the petrous bone. The analytical model predicts well the individual 3D cochlear geometry from few clinical measures and represents a clinical tool for an individualized approach to neurosensory restoration with cochlear implants.
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