Evidence map›Paper›PMID 28790361›Full record

ArticleScientific reports2017

Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2.

Jiabing Fan, Joan Pi-Anfruns, Mian Guo, Dan C S Im, Zhong-Kai Cui, Soyon Kim, Benjamin M Wu, Tara L Aghaloo, Min Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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  11. Rational design of hydrogels to enhance osteogenic potential.Chemistry of materials : a publication of the American Chemical Society · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jiabing FanDivision of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, California, 90095, USA.
Joan Pi-AnfrunsDivision of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, California, 90095, USA.
Mian GuoDepartment of Neurosurgery, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilonjiang, 150001, China.
Dan C S ImDivision of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, California, 90095, USA.
Zhong-Kai CuiDivision of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, California, 90095, USA.ORCID 0000-0003-3112-9379
Soyon KimDepartment of Bioengineering, University of California, Los Angeles, California, 90095, USA.
Benjamin M WuDivision of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, California, 90095, USA.
Tara L AghalooDivision of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, California, 90095, USA. taghaloo@dentistry.ucla.edu.
Min LeeDivision of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, California, 90095, USA. leemin@ucla.edu.
University of California, Los Angeles · USHarbin Medical University · CN

Funding

Combined Effect of Noggin Suppression and Nell-1 on Bone RegenerationR01AR060213 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, MIN · 2011 to 2015
$1.7M
Biomimetic Scaffold Delivering Osteogenic Molecules for Alveolar Bone EngineeringR21DE021819 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, MIN · 2012 to 2013
$416k
NIAMS NIH HHS R01 AR060213NIDCR NIH HHS R21 DE021819
6 · The paper itself

Abstract

Although bone morphogenetic protein-2 (BMP2) has demonstrated extraordinary potential in bone formation, its clinical applications require supraphysiological milligram-level doses that increase postoperative inflammation and inappropriate adipogenesis, resulting in well-documented life-threatening cervical swelling and cyst-like bone formation. Recent promising alternative biomolecular strategies are toward promoting pro-osteogenic activity of BMP2 while simultaneously suppressing its adverse effects. Here, we demonstrated that small molecular phenamil synergized osteogenesis and bone formation with BMP2 in a rat critical size mandibular defect model. Moreover, we successfully elicited the BMP2 adverse outcomes (i.e. adipogenesis and inflammation) in the mandibular defect by applying high dose BMP2. Phenamil treatment significantly improves the quality of newly formed bone by inhibiting BMP2 induced fatty cyst-like structure and inflammatory soft-tissue swelling. The observed positive phenamil effects were associated with upregulation of tribbles homolog 3 (Trib3) that suppressed adipogenic differentiation and inflammatory responses by negatively regulating PPARγ and NF-κB transcriptional activities. Thus, use of BMP2 along with phenamil stimulation or Trib3 augmentation may be a promising strategy to improve clinical efficacy and safety of current BMP therapeutics.

Indexed as

AdipogenesisAmilorideAnimalsBone Density Conservation AgentsBone Morphogenetic Protein 2Bone RegenerationCell DifferentiationDrug SynergismDrug Therapy, CombinationEnzyme ActivationGene Expression RegulationInflammationMaleMandibleMandibular InjuriesMesenchymal Stem CellsAmilorideBmp2 protein, ratBone Density Conservation AgentsBone Morphogenetic Protein 2NF-kappa BphenylamilPPAR gammaProtein Serine-Threonine KinasesTrib3 protein, rat

Identifiers

PMID28790361
PMCPMC5548928
OpenAlexW2740122343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.