ArticleProceedings of the National Academy of Sciences of the United States of America2017
Beyond icosahedral symmetry in packings of proteins in spherical shells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Biogenic nanomaterials: A green strategy for sustainable vector-borne disease management.Pest management science · 2026Review
- Local structural flexibility drives oligomorphism in computationally designed protein assemblies.Nature structural & molecular biology · 2025Article
- Interface flexibility controls the nucleation and growth of supramolecular networks.Nature chemistry · 2025Article
- Effect of ionic strength on the assembly of simian vacuolating virus capsid protein around poly(styrene sulfonate).The European physical journal. E, Soft matter · 2023Article
- Design strategies for the self-assembly of polyhedral shells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Anticancer Activity of Reconstituted Ribonuclease S-Decorated Artificial Viral Capsid.Chembiochem : a European journal of chemical biology · 2022Article
- Thermodynamic Size Control in Curvature-Frustrated Tubules: Self-Limitation with Open Boundaries.ACS nano · 2022Article
- Computational Design of Single-Peptide Nanocages with Nanoparticle Templating.Molecules (Basel, Switzerland) · 2022Article
- Protein-based antigen presentation platforms for nanoparticle vaccines.NPJ vaccines · 2021Review
- De Novo Designed Peptide and Protein Hairpins Self-Assemble into Sheets and Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2021Review
- Connectability of protein cages.Nanoscale advances · 2020Review
- Coiled-Coils: the Molecular Zippers that Self-Assemble Protein Nanostructures.International journal of molecular sciences · 2020Review
- A Modular Vaccine Platform Combining Self-Assembled Peptide Cages and Immunogenic Peptides.Advanced functional materials · 2019Article
- Review
- Bioinspired Silicification Reveals Structural Detail in Self-Assembled Peptide Cages.ACS nano · 2018Article
- Equilibrium mechanisms of self-limiting assembly.Reviews of modern physicsArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The formation of quasi-spherical cages from protein building blocks is a remarkable self-assembly process in many natural systems, where a small number of elementary building blocks are assembled to build a highly symmetric icosahedral cage. In turn, this has inspired synthetic biologists to design de novo protein cages. We use simple models, on multiple scales, to investigate the self-assembly of a spherical cage, focusing on the regularity of the packing of protein-like objects on the surface. Using building blocks, which are able to pack with icosahedral symmetry, we examine how stable these highly symmetric structures are to perturbations that may arise from the interplay between flexibility of the interacting blocks and entropic effects. We find that, in the presence of those perturbations, icosahedral packing is not the most stable arrangement for a wide range of parameters; rather disordered structures are found to be the most stable. Our results suggest that (
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