ArticleThe EMBO journal2017
Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.
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Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 429 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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429citing papers in PubMed, 1 pooled it
27.1field-weighted citation impact, top 1% of its field
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Who cites it
429 citing papers in PubMed, 1 synthesis or guideline pooled it, 701 citations in OpenAlex.
- FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review.Frontiers in molecular neuroscience · 2025Pooled it
- Programmable DNA protonuclei reveal environmental context on protein phase separation.Nature communications · 2026Article
- High-throughput Phosphoproteomics Reveals the Role of Phosphorylation in Pluripotency and Phase Separation.Proteomics · 2026Article
- Phosphoproteomics identifies the DYRK1B protein kinase as a regulator of processing bodies.Journal of cell science · 2026Article
- Beyond the structure-function paradigm: A comprehensive review of intrinsically disordered proteins.Biochemistry and biophysics reports · 2026Review
- FUS controls muscle differentiation through phase separation-mediated recruitment of the transcription factors MEF2 and ETV5.The EMBO journal · 2026Article
- ATRX Condensates as Candidate Organizers of Enhancer-Centered Nuclear Microenvironments in Neural Progenitors: A Hypothesis for Enhancer-Associated ATRX Function in Neural Progenitors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- RSF1-Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multisite Threonine Phosphorylation in the SPT5 C-Terminal Region 1 Enables Sequence-Dependent Regulation without Global Structural Remodeling.The journal of physical chemistry. B · 2026Article
- Molecular Origins of pH Gradients in Charge-Regulated Biomolecular Condensates.bioRxiv : the preprint server for biology · 2026Article
- The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer.Journal of cellular and molecular medicine · 2026Review
- RNA G-quadruplexes function as a tunable switch of FUS phase separation.Nucleic acids research · 2026Article
- Dysregulation of liquid-liquid phase separation: from molecular mechanisms to targeted therapies in cardiovascular diseases.Journal of nanobiotechnology · 2026Review
- The Polymers of Life: Exploring Cellular Function Through Polymer Concepts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Learning molecular determinants of selective small-molecule partitioning across biomolecular condensates.bioRxiv : the preprint server for biology · 2026Article
- PHKG2 confers resistance of ESCC to cisplatin and enhances CXCL8-dependent immunosuppression to exacerbate tumorigenesis.Cell death & disease · 2026Article
- Review
- CCDC120 phase separation contributes to desmosomal integrity and cardiac function.Nature communications · 2026Article
- RNA-Binding Protein TAF15 Suppresses Toxicity in a Yeast Model of FUS Proteinopathy.Journal of fungi (Basel, Switzerland) · 2026Article
- Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
369 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Zachary MonahanDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University, Bethesda, MD, USA.
Veronica H RyanNeuroscience Graduate Program, Brown University, Providence, RI, USA.
Abigail M JankeDepartment of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, USA.
Kathleen A BurkeDepartment of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, USA.
Shannon N RhoadsDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University, Bethesda, MD, USA.
Gül H ZerzeDepartment of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA, USA.
Robert O'MeallyJohns Hopkins Mass Spectrometry and Proteomic Facility, Johns Hopkins University, Baltimore, MD, USA.
Gregory L DignonDepartment of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA, USA.ORCID 0000-0001-8016-8652
Alexander E ConicellaGraduate Program in Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Wenwei ZhengLaboratory of Chemical Physics, National Institutes of Health, Bethesda, MD, USA.
Robert B BestLaboratory of Chemical Physics, National Institutes of Health, Bethesda, MD, USA.
Robert N ColeJohns Hopkins Mass Spectrometry and Proteomic Facility, Johns Hopkins University, Baltimore, MD, USA.
Jeetain MittalDepartment of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA, USA.ORCID 0000-0002-9725-6402
Frank ShewmakerDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University, Bethesda, MD, USA fshewmaker@usuhs.edu nicolas_fawzi@brown.edu.ORCID 0000-0003-2022-0249
Nicolas L FawziNeuroscience Graduate Program, Brown University, Providence, RI, USA fshewmaker@usuhs.edu nicolas_fawzi@brown.edu.ORCID 0000-0001-5483-0577
Brown University · USLehigh University · USUniformed Services University of the Health Sciences · USJohns Hopkins University · USNational Institutes of Health · US
Funding
UTERINE NK CELL HOMING FROM THE PERIPHERAL CIRCULATIONP20RR018728 · NCRR · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI BLISS, JOSEPH MARK · 2003 to 2011
$16.7MUnderstanding protein folding, evolution and function via molecular simulationZIADK075104 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BEST, ROBERT · 2013 to 2025
$13.7MCOBRE for Skeletal Health and RepairP20GM104937 · NIGMS · RHODE ISLAND HOSPITAL · PI CHEN, QIAN · 2012 to 2016
$10.8MInterdisciplinary Predoctoral Neuroscience Training Program in the Neuroscience Graduate Program.T32MH020068 · NIMH · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE, SHEINBERG, DAVID L · 1999 to 2025
$7.6MPilot Projects ProgramP30GM122732 · NIGMS · RHODE ISLAND HOSPITAL · PI CHEN, QIAN · 2017 to 2021
$6.6MTRAINING IN MOLECULAR &CELL BIOLOGY &BIOCHEMISTRYT32GM007601 · NIGMS · BROWN UNIVERSITY · PI MOWRY, KIMBERLY L. · 1985 to 2019
$6.4MCenter for Cancer Signaling NetworksP30GM103410 · NIGMS · BROWN UNIVERSITY · PI ATWOOD, WALTER J · 2012 to 2015
$4.3MTurning off the molecular switch for pathological self-assembly of FUSR01GM118530 · NIGMS · BROWN UNIVERSITY · PI FAWZI, NICOLAS LUX · 2016 to 2020
$1.6MUsing naturally-occurring fungal prions as models of neurodegenerative protein misfoldingR35GM119790 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI FENG, YUANYI · 2016 to 2020
$1.4MCENTER FOR CANCER SIGNALING NETWORKSP30RR031153 · NCRR · BROWN UNIVERSITY · PI ATWOOD, WALTER J · 2011 to 2011
$1.1MAcquisition of an Orbitrap XL ETD Mass Spectrometer through Upgrading an LTQS10RR027027 · NCRR · BROWN UNIVERSITY · PI HAWROT, EDWARD · 2010 to 2010
$500kCD SPECTROPHOTOMETER: STRUCTURAL BIOL, PROTEIN, MOLECULAR PHARMACOLOGYS10RR020923 · NCRR · BROWN UNIVERSITY · PI MIERKE, DALE F · 2006 to 2006
$105kNCRR NIH HHS P20 RR018728NCRR NIH HHS P30 RR031153NCRR NIH HHS S10 RR020923NCRR NIH HHS S10 RR027027NIGMS NIH HHS P20 GM104937NIGMS NIH HHS P30 GM103410NIGMS NIH HHS P30 GM122732NIGMS NIH HHS R01 GM118530NIGMS NIH HHS R35 GM119790NIGMS NIH HHS T32 GM007601NIMH NIH HHS T32 MH020068
Abstract
Neuronal inclusions of aggregated RNA-binding protein fused in sarcoma (FUS) are hallmarks of ALS and frontotemporal dementia subtypes. Intriguingly, FUS's nearly uncharged, aggregation-prone, yeast prion-like, low sequence-complexity domain (LC) is known to be targeted for phosphorylation. Here we map
Indexed as
Protein Processing, Post-TranslationalAmyotrophic Lateral SclerosisCell LineFrontotemporal DementiaHumansMagnetic Resonance SpectroscopyPhosphorylationProtein Aggregation, PathologicalProtein ConformationRNA-Binding Protein FUSFUS protein, humanRNA-Binding Protein FUSamyotrophic lateral sclerosisfrontotemporal dementiaintrinsically disordered proteinprionribonucleoprotein granule
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.