Evidence map›Paper›PMID 28790168›Full record

ArticleBioscience reports2017

MicroRNA-211/BDNF axis regulates LPS-induced proliferation of normal human astrocyte through PI3K/AKT pathway.

Kexiang Zhang, Song Wu, Zhiyue Li, Jiahui Zhou

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 53 citations in OpenAlex.

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  9. Protein kinase B (AKT) upregulation and Thy-1-αJournal of neuroinflammation · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kexiang ZhangDepartment of Orthopedics, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Song WuDepartment of Orthopedics, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhiyue LiDepartment of Orthopedics, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Jiahui ZhouDepartment of Orthopedics, The Third Xiangya Hospital, Central South University, Changsha 410013, China zjh5518@sina.com.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) makes a major contribution to disability and deaths worldwide. Reactive astrogliosis, a typical feature after SCI, which undergoes varying molecular and morphological changes, is ubiquitous but poorly understood. Reactive astrogliosis contributes to glial scar formation that impedes axonal regeneration. Brain-derived neurotrophic factor (BDNF), a well-established neurotrophic factor, exerts neuroprotective and growth-promoting effects on a variety of neuronal populations after injury. In the present study, by using LPS-induced

Indexed as

3' Untranslated RegionsAstrocytesBrain-Derived Neurotrophic FactorCell ProliferationCells, CulturedCicatrixDose-Response Relationship, DrugDown-RegulationHEK293 CellsHumansLipopolysaccharidesMicroRNAsPhosphatidylinositol 3-KinaseProto-Oncogene Proteins c-aktSpinal Cord Injuries3' Untranslated RegionsBDNF protein, humanBrain-Derived Neurotrophic FactorLipopolysaccharidesMicroRNAsMIRN211 microRNA, humanPhosphatidylinositol 3-KinaseProto-Oncogene Proteins c-aktBrain-derived Neurotrophic Factor (BDNF)miR-211normal human astrocyte (NHA)proliferationspinal cord injury (SCI)

Identifiers

PMID28790168
PMCPMC5563540
OpenAlexW2744634653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.