Evidence map›Paper›PMID 28790115›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

MSH2 Loss in Primary Prostate Cancer.

Liana B Guedes, Emmanuel S Antonarakis, Michael T Schweizer, Nooshin Mirkheshti, Fawaz Almutairi, Jong Chul Park, Stephanie Glavaris, Jessica Hicks, Mario A Eisenberger, Angelo M De Marzo and 5 more

Open access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Prevalence of Mismatch Repair Deficiency in Primary Prostate Cancer in a Large Prospective Cohort.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Liana B GuedesDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Emmanuel S AntonarakisDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Michael T SchweizerDepartment of Medicine, Division of Oncology, University of Washington, Seattle, Washington.
Nooshin MirkheshtiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Fawaz AlmutairiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jong Chul ParkDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Stephanie GlavarisDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jessica HicksDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Mario A EisenbergerDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Angelo M De MarzoDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jonathan I EpsteinDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
William B IsaacsBrady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
James R EshlemanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Colin C PritchardDepartment of Laboratory Medicine, University of Washington, Seattle, Washington.
Tamara L LotanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. tlotan1@jhmi.edu.
Johns Hopkins University · USUniversity of Washington · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
TRANSCRIPTOME AND PROTEOME STRATIFICATION OF PROSTATE ADENOCARCINOMA PHENOTYPESP50CA097186 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETER S NELSON · 2002 to 2026
$58.1M
TRANSGENIC MODELS FOR PROSTATE CANCER AND AUTOIMMUNITYP50CA058236 · NCI · JOHNS HOPKINS UNIVERSITY · PI DENMEADE, SAMUEL R · 1992 to 2020
$43.9M
NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA015704NCI NIH HHS P50 CA058236NCI NIH HHS P50 CA097186
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedBiomarkers, TumorDNA Mismatch RepairGenomicsGerm-Line MutationHigh-Throughput Nucleotide SequencingHumansImmunohistochemistryLoss of Function MutationLymphocytes, Tumor-InfiltratingMaleMicrosatellite InstabilityMiddle AgedMutS Homolog 2 ProteinNeoplasm GradingBiomarkers, TumorMSH2 protein, humanMutS Homolog 2 Protein

Identifiers

PMID28790115
PMCPMC5690834
OpenAlexW2743298940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.