ArticleDevelopmental biology2017
BMP2 expression in the endocardial lineage is required for AV endocardial cushion maturation and remodeling.
Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration.Frontiers in cardiovascular medicine · 2022Pooled it
- Hyaluronan in cardiac disease: implications for the extracellular matrix beyond collagen.American journal of physiology. Heart and circulatory physiology · 2026Review
- Mechanisms of mitral valve development and disease.Frontiers in cardiovascular medicine · 2026Review
- Impact of genetic factors on antioxidant rescue of maternal diabetes-associated congenital heart disease.JCI insight · 2024Article
- Identification of two miRNAs regulating cardiomyocyte proliferation in an Antarctic icefish.iScience · 2024Article
- Kielin/chordin-like protein deficiency causes cardiac aging in male mice.Journal of molecular medicine (Berlin, Germany) · 2023Article
- Wnt Signaling in Heart Development and Regeneration.Current cardiology reports · 2022Review
- Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2.Development (Cambridge, England) · 2022Article
- Endocardial Regulation of Cardiac Development.Journal of cardiovascular development and disease · 2022Review
- Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis.International journal of molecular sciences · 2022Review
- Local fluid shear stress operates a molecular switch to drive fetal semilunar valve extension.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Valve endothelial-interstitial interactions drive emergent complex calcific lesion formation in vitro.Biomaterials · 2021Article
- Coxsackievirus B3 Infection Early in Pregnancy Induces Congenital Heart Defects Through Suppression of Fetal Cardiomyocyte Proliferation.Journal of the American Heart Association · 2021Article
- The Endocardium and Heart Valves.Cold Spring Harbor perspectives in biology · 2020Review
- The Mesenchymal Cap of the Atrial Septum and Atrial and Atrioventricular Septation.Journal of cardiovascular development and disease · 2020Review
- Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation.Circulation research · 2020Review
- Real-Ambient Particulate Matter Exposure-Induced Cardiotoxicity in C57/B6 Mice.Frontiers in pharmacology · 2020Article
- Myocardial differentiation is dependent upon endocardial signaling during early cardiogenesisDevelopment (Cambridge, England) · 2019Article
- Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation.Journal of molecular and cellular cardiology · 2018Article
- Calcific Aortic Valve Disease: a Developmental Biology Perspective.Current cardiology reports · 2018Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Distal outgrowth, maturation and remodeling of the endocardial cushion mesenchyme in the atrioventricular (AV) canal are the essential morphogenetic events during four-chambered heart formation. Mesenchymalized AV endocardial cushions give rise to the AV valves and the membranous ventricular septum (VS). Failure of these processes results in several human congenital heart defects. Despite this clinical relevance, the mechanisms governing how mesenchymalized AV endocardial cushions mature and remodel into the membranous VS and AV valves have only begun to be elucidated. The role of BMP signaling in the myocardial and secondary heart forming lineage has been well studied; however, little is known about the role of BMP2 expression in the endocardial lineage. To fill this knowledge gap, we generated Bmp2 endocardial lineage-specific conditional knockouts (referred to as Bmp2 cKO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.