SynthesisJournal of psychosomatic research2017
Relationship between perceived fatigue and performance fatigability in people with multiple sclerosis: A systematic review and meta-analysis.
Synthesis in Journal of psychosomatic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 77 citations in OpenAlex.
- Dissociating Fatigue and Fatigability in Multiple Sclerosis: The Role of Cognitive Processing Speed.European journal of neurology · 2026Article
- Broadening the understanding of fatigue in multiple sclerosis: a qualitative study protocol of the EMA-FAMS project.BMJ open · 2026Article
- Evaluation of the construct validity of the Michigan Fatigability Index (MIFI) short forms: a cross-sectional survey study.Journal of patient-reported outcomes · 2026Article
- Motor fatigue and fatigability in early multiple sclerosis patients: an analysis of clinical, radiological and psychological underpinnings.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Predictive processes linking sense of agency and fatigue: a novel allostatic framework.Frontiers in psychology · 2026Article
- Fatigue: a common but poorly understood symptom in neurological and non-neurological diseases.Nature reviews. Neurology · 2025Review
- Predicting Real-World Physical Activity in Multiple Sclerosis: An Integrated Approach Using Clinical, Sensor-Based, and Self-Reported Measures.Sensors (Basel, Switzerland) · 2025Article
- Smartphone-based gait analysis in the assessment of fatigue and fatigability in people with multiple sclerosis: a supervised cohort study.Journal of neurology · 2025Article
- Associations between skeletal muscle energetics and accelerometry-based performance fatigability: Study of Muscle, Mobility and Aging.Aging cell · 2024Article
- Article
- Validation of the Pittsburgh Performance Fatigability Index in the Study of Muscle, Mobility and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Upper-Limb Kinematic Behavior and Performance Fatigability of Elderly Participants Performing an Isometric Task: A Quasi-Experimental Study.Bioengineering (Basel, Switzerland) · 2023Article
- Post-stroke fatigue: a review of development, prevalence, predisposing factors, measurements, and treatments.Frontiers in neurology · 2023Review
- Measuring and Understanding the Health Impact of Greater Fatigability in Older Adults: A Call to Action and Opportunities.Fatigue : biomedicine, health & behavior · 2023Article
- Article
- Article
- The Association Between Actigraphy-Derived Behavioral Clusters and Self-Reported Fatigue in Persons With Multiple Sclerosis: Cross-sectional Study.JMIR rehabilitation and assistive technologies · 2022Article
- Factor structure, reliability, inter-rater agreement and convergent validity of the parent and child Italian versions of the paediatric quality of life inventory multidimensional fatigue scale for children and adolescents in paediatric inpatients with obesity and their parents.Eating and weight disorders : EWD · 2022Article
- How is neuromuscular fatigability affected by perceived fatigue and disability in people with multiple sclerosis?Frontiers in neurology · 2022Review
- The pathophysiology of motor fatigue and fatigability in multiple sclerosis.Frontiers in neurology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPerceived fatigue (i.e., subjective perception of reduced capacity) is one of the most common and disabling symptoms for people with multiple sclerosis (MS). Perceived fatigue may also be related to performance fatigability (i.e., decline in physical performance over time), although study findings have been inconsistent.
objectiveTo locate all studies reporting the relationship between perceived fatigue and fatigability in people with MS, determine the population correlation, and examine moderating variables of the correlation size.
methodsIn accordance with PRISMA guidelines, systematic searches were completed in Medline, PsychInfo, Google Scholar, and the Cochrane Library for peer-reviewed articles published between March 1983 and August 2016. Included articles measured perceived fatigue and performance fatigability in people with MS and provided a correlation between measures. Moderator variables expected to influence the relationship were also coded. Searches located 19 studies of 848 people with MS and a random-effects model was used to pool correlations.
resultsThe mean correlation between fatigue and fatigability was positive, "medium" in magnitude, and statistically significant, r=0.31 (95% CI=0.21, 0.42), p<0.001. Despite moderate between-study heterogeneity (I
conclusionThere is a significant relationship between perceived fatigue and fatigability in MS, such that people reporting elevated fatigue also are highly fatigable. The size of the relationship is not large enough to suggest fatigue and fatigability are the same construct, and both should continue to be assessed independently.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.