ArticleMicrobiome2017
Transplanted human fecal microbiota enhanced Guillain Barré syndrome autoantibody responses after Campylobacter jejuni infection in C57BL/6 mice.
Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 43 citations in OpenAlex.
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- Dynamic Spread of Antibiotic Resistance Determinants by Conjugation to a Human-Derived Gut Microbiota in a Transplanted Mouse Model.Antibiotics (Basel, Switzerland) · 2025Article
- Pathogenic mechanism of intestinal microbiota involved in Guillain-Barré syndrome and withArchives of medical science : AMS · 2025Article
- Guillain-Barré Syndrome Following Laparoscopic Sleeve Gastrectomy: A Tale of Two Cases.Obesity surgery · 2025Article
- Lactobacillus rhamnosus ameliorates experimental autoimmune neuritis via modulation of gut microbiota and metabolites.Heliyon · 2024Article
- Antibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN).Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- Alterations of oral microbiome and metabolic signatures and their interaction in oral lichen planus.Journal of oral microbiology · 2024Article
- Campylobacter in Africa - A specific viewpoint.European journal of microbiology & immunology · 2023Review
- Evidence of potentialMicrobial genomics · 2023Article
- Intestinal Barrier in Post-Biomolecules · 2023Article
- Molecular Targets inBiomolecules · 2023Review
- Conjugative RP4 Plasmid-Mediated Transfer of Antibiotic Resistance Genes to Commensal and Multidrug-Resistant Enteric Bacteria In Vitro.Microorganisms · 2023Article
- The role of the gut microbiota and fecal microbiota transplantation in neuroimmune diseases.Frontiers in neurology · 2023Review
- Fecal microbiota transplantation fromFrontiers in microbiology · 2023Article
- The epithelial transcriptome and mucosal microbiota are altered for goats fed with a low-protein diet.Frontiers in microbiology · 2023Article
- From germ-free to wild: modulating microbiome complexity to understand mucosal immunology.Mucosal immunology · 2022Review
- Th1/Th17-mediated Immunity and Protection from Peripheral Neuropathy in Wildtype and IL10Comparative medicine · 2022Article
- Article
- Relationships between gut microbiota, plasma glucose and gestational diabetes mellitus.Journal of diabetes investigation · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCampylobacter jejuni is the leading antecedent infection to the autoimmune neuropathy Guillain-Barré syndrome (GBS), which is accompanied by an autoimmune anti-ganglioside antibody attack on peripheral nerves. Previously, we showed that contrasting immune responses mediate C. jejuni induced colitis and autoimmunity in interleukin-10 (IL-10)-deficient mice, dependent upon the infecting strain. Strains from colitis patients elicited T helper 1 (T
methodsUsing 16S rRNA gene high-throughput sequencing, we examined whether structure of the gut microbial community alters host (1) gastrointestinal inflammation or (2) anti-ganglioside antibody responses after infection with C. jejuni strains from colitis or GBS patients. We compared these responses in C57BL/6 mice with either (1) stable human gut microbiota (
resultsInoculating germ-free C57BL/6 wild-type (WT) mice with a mixed human fecal slurry provided a murine model that stably passed its microbiota over >20 generations. Mice were housed in specific pathogen-free (SPF) facilities, while extra precautions of having caretakers wear sterile garb along with limited access ensured that no mouse pathogens were acquired.
conclusionsThese data demonstrate that
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.