ArticleBiology of sex differences2017
Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients.
Article in Biology of sex differences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.Rheumatology (Oxford, England) · 2025Guideline
- Article
- Frequency and Impact of Serious Infections in Hospitalised Patients with Sjögren's Disease: A Longitudinal Cohort Study.Rheumatology and therapy · 2026Article
- Sex differences in primary Sjögren's disease: prognostic impact on mortality and cancer.Biology of sex differences · 2026Observational
- Exploring gender-related clinical and immunological profiles in Sjögren's disease in a Chinese cohort.Clinical rheumatology · 2025Article
- Clinical Characteristics, Imaging Patterns and Management in Male and Female Patients with Primary Sjögren's Syndrome-associated Interstitial Lung Disease.Clinical rheumatology · 2025Article
- Evaluation of patients diagnosed with primary Sjogren's syndrome with and without pulmonary involvement.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025Article
- Tlr9 expression protects against Tlr7-dependent exocrine gland and systemic disease manifestations in primary Sjögren's disease in a sex-biased manner.Journal of autoimmunity · 2025Article
- A high polygenic risk score is associated with SSA/SSB antibody positivity and early onset in primary Sjögren's disease.Rheumatology (Oxford, England) · 2025Article
- Article
- In-Depth Analysis of Disease Manifestations in Antineutrophil Cytoplasmic Antibody-Associated Vasculitides Identifies Distinct Clinical Phenotypes.ACR open rheumatology · 2025Article
- Prevalence of Interstitial Lung Disease in Patients with Primary Sjogren's Syndrome: A Systematic Review and Meta-analysis of Observational Studies : Prevalence of Interstitial Lung Disease in Patients with Primary Sjogren's Syndrome.Galen medical journal · 2025Review
- Long-term outcome of interstitial lung disease in patients with primary Sjögren's syndrome: a retrospective observational study.The Korean journal of internal medicine · 2025Observational
- Male patients with primary Sjögren's syndrome have unique clinical manifestations and circulating lymphocyte profiles.Clinical rheumatology · 2024Article
- Maternal-fetal outcomes in patients with immune-mediated inflammatory diseases, with consideration of comorbidities: a retrospective cohort study in a large U.S. healthcare system.EClinicalMedicine · 2024Article
- Characteristics of primary Sjogren's syndrome with articular manifestations at initial treatment.SAGE open medicine · 2024Article
- Interstitial Lung Disease and Pulmonary Damage in Primary Sjögren's Syndrome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Metabolic Profile of Whole Unstimulated Saliva in Patients with Sjögren's Syndrome.Metabolites · 2023Article
- Sex-specific differences in primary Sjögren's disease.Frontiers in dental medicine · 2023Review
- [Evaluation of ocular surface status and function in primary Sjögren's syndrome with hypothyroidism].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundDespite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigate differences in the clinical presentation of primary Sjögren's syndrome (pSS) between the sexes and establish whether male sex is associated with a more severe form of long-term pSS.
methodsOur study population included 967 patients with pSS (899 females and 68 males) from Scandinavian clinical centers. The mean follow-up time (years) was 8.8 ± 7.6 for women and 8.5 ± 6.2 for men (ns). Clinical data including serological and hematological parameters and glandular and extraglandular manifestations were compared between men and women.
resultsMale patient serology was characterized by more frequent positivity for anti-Ro/SSA and anti-La/SSB (p = 0.02), and ANA (p = 0.02). Further, men with pSS were more frequently diagnosed with interstitial lung disease (p = 0.008), lymphadenopathy (p = 0.04) and lymphoma (p = 0.007). Conversely, concomitant hypothyroidism was more common among female patients (p = 0.009).
conclusionsWe observe enhanced serological responses and higher frequencies of lymphoma-related extraglandular manifestations in men with pSS. Notably, lymphoma itself was also significantly more common in men. These observations may reflect an aggravated immune activation and a more severe pathophysiological state in male patients with pSS and indicate a personalized managing of the disease due to the influence of the sex of patients with pSS.
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