Evidence map›Paper›PMID 28789585›Full record

ArticleDrug delivery2017

Co-delivery of docetaxel and bortezomib based on a targeting nanoplatform for enhancing cancer chemotherapy effects.

Junpeng Nie, Wei Cheng, Yunmei Peng, Gan Liu, Yuhan Chen, Xusheng Wang, Chaoyu Liang, Wei Tao, Yinping Wei, Xiaowei Zeng and 1 more

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 55 citations in OpenAlex.

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  17. Polydopamine-Functionalized CA-(PCL-Frontiers in pharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Junpeng Niea School of Life Sciences , Tsinghua University , Beijing , PR China.
Wei Chengb Graduate School at Shenzhen , Tsinghua University , Shenzhen , PR China.
Yunmei Penga School of Life Sciences , Tsinghua University , Beijing , PR China.
Gan Liuc School of Pharmaceutical Sciences (Shenzhen) , Sun Yat-sen University , Guangzhou , PR China.
Yuhan Chend Department of Radiation Oncology , Zhongshan Hospital, Fudan University , Shanghai , PR China.
Xusheng Wanga School of Life Sciences , Tsinghua University , Beijing , PR China.
Chaoyu Liangb Graduate School at Shenzhen , Tsinghua University , Shenzhen , PR China.
Wei Taoe Brigham and Women's Hospital , Harvard Medical School , Boston , MA , USA.
Yinping Weib Graduate School at Shenzhen , Tsinghua University , Shenzhen , PR China.
Xiaowei Zenga School of Life Sciences , Tsinghua University , Beijing , PR China.ORCID http://orcid.org/0000-0002-2804-2689
Lin Meib Graduate School at Shenzhen , Tsinghua University , Shenzhen , PR China.
University Town of Shenzhen · CNSun Yat-sen University · CNBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using facile polydopamine (PDA)-based surface modification and a pH-sensitive catechol-boronate binding mechanism, a novel drug delivery system was designed for the treatment of breast cancer. The system was able to achieve the following goals: active targeting, pH responsiveness, in vivo blood circulation for a prolonged period of time, and dual drug loading. After coating with PDA, the docetaxel (DTX)-loaded star-shaped copolymer cholic acid-poly(lactide-co-glycolide) nanoparticles (CA-PLGA@PDA/NPs) were functionalized with amino-poly(ethylene glycol)-folic acid (NH

Indexed as

NanoparticlesBortezomibDocetaxelHumansLactic AcidNeoplasmsTaxoidsTissue DistributionBortezomibDocetaxelLactic AcidTaxoidsCancer nanotechnologyco-deliverypH-responsepolydopaminetargeting nanoplatform

Identifiers

PMID28789585
PMCPMC8241102
OpenAlexW2742848079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.