Evidence map›Paper›PMID 28789367›Full record

ArticleOncology letters2017

α-taxilin overexpression correlates with proliferation activity but not with prognosis of colorectal cancer.

Akira Kanamori, Yasuo Imai, Keisuke Ihara, Hitoshi Nagata, Masakazu Nakano, Keiichi Tominaga, Hiroaki Shimizu, Tomihiko Makiyama, Hajime Kuroda, Hiromichi Shirataki and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Akira KanamoriDepartment of Gastroenterology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
Yasuo ImaiDepartment of Diagnostic Pathology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
Keisuke IharaDepartment of Surgical Oncology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
Hitoshi NagataDepartment of Gastroenterological Surgery, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
Masakazu NakanoDepartment of Gastroenterology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
Keiichi TominagaDepartment of Gastroenterology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
Hiroaki ShimizuDepartment of Molecular and Cell Biology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
Tomihiko MakiyamaDepartment of Molecular and Cell Biology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
Hajime KurodaDepartment of Diagnostic Pathology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
Hiromichi ShiratakiDepartment of Molecular and Cell Biology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
Hideyuki HiraishiDepartment of Gastroenterology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan.
Dokkyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

α-taxilin is a binding partner of syntaxins, which are the central coordinators of membrane traffic. Expression of α-taxilin has been implicated in the development of human glioblastoma, hepatocellular carcinoma and renal cell carcinoma. In the present study, the clinical significance of α-taxilin expression in colorectal cancer (CRC) was investigated. A total of 20 cases of colorectal intramucosal adenocarcinoma (IMA) with adenoma were analyzed using immunohistochemical analysis. The results demonstrated that α-taxilin expression was significantly associated with Ki-67 indices in adenoma and IMA. The patients expressed equally high levels of α-taxilin in the upper third of the intramucosal glands. These results suggest that α-taxilin expression is significantly associated with the proliferative activity of CRC, but that its overexpression alone is not a biomarker of malignancy. Next, α-taxilin expression was investigated in 57 advanced CRCs and its association with prognosis was determined. Well-differentiated and/or moderately differentiated adenocarcinomas in the left-sided colon with anatomic stage II and/or III were analyzed. α-taxilin expression levels were high on the surface of nearly all tumors, but variable at the deep advancing edge. α-taxilin levels at the advancing edge were not significantly associated with local invasiveness or prognosis. In conclusion, α-taxilin is a cell proliferation marker in colorectal epithelial neoplasms but cannot be a marker of malignancy or prognosis of CRCs.

Indexed as

colorectal cancerKi-67prognosisproliferationα-taxilin

Identifiers

PMID28789367
PMCPMC5529874
OpenAlexW2620890592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.