Evidence map›Paper›PMID 28789346›Full record

ArticleOncology letters2017

Ankylosing spondylitis and the risk of cancer.

Chih-Cheng Chang, Cheng-Wei Chang, Phung-Anh Alex Nguyen, Tzu-Hao Chang, Ya-Ling Shih, Wen-Ying Chang, Jorng-Tzong Horng, Oscar Kuang-Sheng Lee, Jennifer Hui-Chun Ho

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. A Review of the Safety of Interleukin-17A Inhibitor Secukinumab.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. HLA-B27 association of autoimmune encephalitis induced by PD-L1 inhibitor.Annals of clinical and translational neurology · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Chih-Cheng ChangDepartment of Internal Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan, R.O.C.
Cheng-Wei ChangDepartment of Information Management, Hsing Wu University, New Taipei 244, Taiwan, R.O.C.
Phung-Anh Alex NguyenCollege of Medical Science & Technology, Taipei Medical University, Taipei 110, Taiwan, R.O.C.
Tzu-Hao ChangGraduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan, R.O.C.
Ya-Ling ShihDepartment of Nursing, En Chu Kong Hospital, New Taipei 237, Taiwan, R.O.C.
Wen-Ying ChangDepartment of Electrical Engineering, National Cheng-Kung University, Tainan 701, Taiwan, R.O.C.
Jorng-Tzong HorngDepartment of Biomedical Informatics, Asia University, Taichung 413, Taiwan, R.O.C.
Oscar Kuang-Sheng LeeInstitute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan, R.O.C.
Jennifer Hui-Chun HoCenter for Stem Cell Research and Clinical Trial, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan, R.O.C.
Hsing Wu University · TWTaipei Medical University · TWAsia University · TWEn Chu Kong Hospital · TWNational Cheng Kung University · TWNational Yang Ming Chiao Tung University · TWWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a multifactorial disease, and imbalances of the immune response and sex-associated features are considered risk factors for certain types of cancer. The present study aimed to assess whether ankylosing spondylitis (AS), an immune disorder that predominantly affects young adult men, is associated with an increased risk of cancer. Using the Taiwan National Health Insurance Research Database, a cohort of patients diagnosed with AS between 2000 and 2008 who had no history of cancer prior to enrollment was established (n=5,452). Age- and sex-matched patients without AS served as controls (n=21,808). The results revealed that the overall incidence of cancer was elevated in patients with AS [standardized incidence ratio (SIR), 1.15; 95% confidence interval (CI), 1.03-1.27]. AS carried an increased risk of hematological malignancy in both sexes, colon cancer in females and bone and prostate cancer in males. Young patients with AS (≤35 years) and patients with a Charlson comorbidity index (CCI) ≥2 experienced a higher incidence of cancer (males, SIR 1.92, and 95% CI 1.04-3.26; females, SIR 2.00 and 95% CI 1.46-5.50). The cancer risk was increased during the first 3 years following the diagnosis of AS (SIR 1.49, 95% CI 1.29-1.71), and overall cancer-free survival was significantly decreased in patients with AS patients of both sexes (P<0.0001). Therefore, AS was found to be associated with an increased risk of cancer. All AS patients must be screened for hematological malignancies, for prostate and bone cancer in males, and for colon cancer in females, particularly younger patients with a CCI ≥2.

Indexed as

age groupsankylosing spondylitiscancercohortcomorbiditysex

Identifiers

PMID28789346
PMCPMC5529950
OpenAlexW2623158655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.