ArticleOptics express2017
Noninvasive chorioretinal imaging in living rabbits using integrated photoacoustic microscopy and optical coherence tomography.
Article in Optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Blind single image restoration for ring-array photoacoustic tomography system via physics-aided unsupervised learning.Photoacoustics · 2026Article
- Physics-driven deep learning photoacoustic tomography.Fundamental research · 2026Article
- TT-PADM: A Time-Driven Transformer Diffusion Model for Robust Sparse-View and Limited-View Photoacoustic Tomography.BME frontiers · 2026Article
- Imaging techniques for the detection of choroidal neovascularization.Experimental eye research · 2025Review
- Multimodal retinal imaging evaluation of macular degeneration persistent disease activity animal model in Watanabe heritable hyperlipidemic rabbits.Experimental eye research · 2025Article
- Image restoration for ring-array photoacoustic tomography based on an attention mechanism driven conditional generative adversarial network.Photoacoustics · 2025Article
- Ultrafast filtered back-projection for photoacoustic computed tomography.Biomedical optics express · 2025Article
- Selective nanosecond laser removal of retinal pigment epithelium for cell therapy.Scientific reports · 2024Article
- Image restoration for ring-array photoacoustic tomography system based on blind spatially rotational deconvolution.Photoacoustics · 2024Article
- Advances in Structural and Functional Retinal Imaging and Biomarkers for Early Detection of Diabetic Retinopathy.Biomedicines · 2024Review
- Molecular and cellular imaging of the eye.Biomedical optics express · 2024Review
- Advanced nanomaterials for imaging of eye diseases.ADMET & DMPK · 2024Review
- 3D imaging of aqueous veins and surrounding sclera using a dual-wavelength photoacoustic microscopy.Biomedical optics express · 2023Article
- Renally Clearable Ultraminiature Chain-Like Gold Nanoparticle Clusters for Multimodal Molecular Imaging of Choroidal Neovascularization.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Multimodal imaging of laser-induced choroidal neovascularization in pigmented rabbits.Scientific reports · 2023Article
- USH2A Gene Mutations in Rabbits Lead to Progressive Retinal Degeneration and Hearing Loss.Translational vision science & technology · 2023Article
- Age differential response to bevacizumab therapy in choroidal neovascularization in rabbits.Experimental eye research · 2022Article
- In-vivo functional and structural retinal imaging using multiwavelength photoacoustic remote sensing microscopy.Scientific reports · 2022Article
- Safety Evaluation of Photoacoustic Tomography System for Intraocular Tumors.Translational vision science & technology · 2022Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most reported photoacoustic ocular imaging work to date uses small animals, such as mice and rats, the eyeball sizes of which are less than one-third of those of humans, posing challenges for clinical translation. Here we developed a novel integrated photoacoustic microscopy (PAM) and optical coherence tomography (OCT) system for dual-modality chorioretinal imaging of larger animals, such as rabbits. The system has quantified lateral resolutions of 4.1 µm (PAM) and 3.8 µm (OCT), and axial resolutions of 37.0 µm (PAM) and 4.0 µm (OCT) at the focal plane of the objective. Experimental results in living rabbits demonstrate that the PAM can noninvasively visualize individual depth-resolved retinal and choroidal vessels using a laser exposure dose of ~80 nJ below the American National Standards Institute (ANSI) safety limit 160 nJ at 570 nm; and the OCT can finely distinguish different retinal layers, the choroid, and the sclera. This reported work may be a major step forward in clinical translation of the technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.