ReviewMaterials (Basel, Switzerland)2014
Fabrication of Metallic Biomedical Scaffolds with the Space Holder Method: A Review.
Review in Materials (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Nanocomposite Bone Scaffolds Based on Magnesium Alloy: A Detailed Investigation of Their In-Vitro Biodegradation Performance.International journal of biomaterials · 2026Article
- Article
- Biomineral-Based Composite Materials in Regenerative Medicine.International journal of molecular sciences · 2024Review
- Forged to heal: The role of metallic cellular solids in bone tissue engineering.Materials today. Bio · 2023Article
- Design of Ti64/Ta Hybrid Materials by Powder Metallurgy Mimicking Bone Structure.Materials (Basel, Switzerland) · 2023Article
- An Investigation into the Potential of Turning Induced Deformation Technique for Developing Porous Magnesium and Mg-SiOMaterials (Basel, Switzerland) · 2023Article
- Magnesium-based alloys with adapted interfaces for bone implants and tissue engineering.Regenerative biomaterials · 2023Review
- Experimental Analysis and Parametric Optimization on Compressive Properties of Diamond-Reinforced Porous Al Composites.Materials (Basel, Switzerland) · 2022Article
- Structural Characterization Analyses of Low Brass Filler Biomaterial for Hard Tissue Implanted Scaffold Applications.Materials (Basel, Switzerland) · 2022Article
- Article
- Low Mg content on Ti-Nb-Sn alloy when in contact with eBMMSCs promotes improvement of its biological functions.Journal of materials science. Materials in medicine · 2021Article
- Macro-, meso- and microstructural characterization of metallic lattice structures manufactured by additive manufacturing assisted investment casting.Scientific reports · 2021Article
- Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications.Materials (Basel, Switzerland) · 2021Review
- Corrosion and wear behaviour of highly porous Ti-TiB-TiNTurkish journal of chemistry · 2020Article
- Bioactive scaffolds for osteochondral regeneration.Journal of orthopaedic translation · 2019Review
- Design and Compressive Behavior of a Photosensitive Resin-Based 2-D Lattice Structure with Variable Cross-Section Core.Polymers · 2019Article
- Novel fabrication of porous titanium by a resin-impregnated titanium substitution technique for bone reconstruction.RSC advances · 2019Article
- Influence of the electrolyte's pH on the properties of electrochemically deposited hydroxyapatite coating on additively manufactured Ti64 alloy.Scientific reports · 2017Article
- Fabrication and Compressive Properties of Low to Medium Porosity Closed-Cell Porous Aluminum Using PMMA Space Holder Technique.Materials (Basel, Switzerland) · 2016Article
- Biological strategies for improved osseointegration and osteoinduction of porous metal orthopedic implants.Tissue engineering. Part B, Reviews · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone tissue engineering has been increasingly studied as an alternative approach to bone defect reconstruction. In this approach, new bone cells are stimulated to grow and heal the defect with the aid of a scaffold that serves as a medium for bone cell formation and growth. Scaffolds made of metallic materials have preferably been chosen for bone tissue engineering applications where load-bearing capacities are required, considering the superior mechanical properties possessed by this type of materials to those of polymeric and ceramic materials. The space holder method has been recognized as one of the viable methods for the fabrication of metallic biomedical scaffolds. In this method, temporary powder particles, namely space holder, are devised as a pore former for scaffolds. In general, the whole scaffold fabrication process with the space holder method can be divided into four main steps: (i) mixing of metal matrix powder and space-holding particles; (ii) compaction of granular materials; (iii) removal of space-holding particles; (iv) sintering of porous scaffold preform. In this review, detailed procedures in each of these steps are presented. Technical challenges encountered during scaffold fabrication with this specific method are addressed. In conclusion, strategies are yet to be developed to address problematic issues raised, such as powder segregation, pore inhomogeneity, distortion of pore sizes and shape, uncontrolled shrinkage and contamination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.