Evidence map›Paper›PMID 28788609›Full record

ReviewMaterials (Basel, Switzerland)2014

Gelatin-Based Materials in Ocular Tissue Engineering.

James B Rose, Settimio Pacelli, Alicia J El Haj, Harminder S Dua, Andrew Hopkinson, Lisa J White, Felicity R A J Rose

Abstract readReview
In one paragraph

Review in Materials (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed.

  1. Article
  2. Review
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  7. Article
  8. Review
  9. Transient Catalase Immobilization for Cytoprotection during HACS biomaterials science & engineering · 2025
    Article
  10. Nanotherapy for Neural Retinal Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
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  19. Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James B RoseSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK. paxjr@nottingham.ac.uk.
Settimio PacelliDepartment of Drug Chemistry and Technologies, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. settimio.pacelli@uniroma1.it.
Alicia J El HajInstitute for Science and Technology in Medicine, Keele University, Stoke-on-Trent ST4 7QB, UK. a.j.el.haj@keele.ac.uk.
Harminder S DuaAcademic Ophthalmology, Division of Clinical Neuroscience, University of Nottingham, Nottingham NG7 2RD, UK. harminder.dua@nottingham.ac.uk.
Andrew HopkinsonAcademic Ophthalmology, Division of Clinical Neuroscience, University of Nottingham, Nottingham NG7 2RD, UK. andrew.hopkinson@nottingham.ac.uk.
Lisa J WhiteSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK. lisa.white@nottingham.ac.uk.
Felicity R A J RoseSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK. felicity.rose@nottingham.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gelatin has been used for many years in pharmaceutical formulation, cell culture and tissue engineering on account of its excellent biocompatibility, ease of processing and availability at low cost. Over the last decade gelatin has been extensively evaluated for numerous ocular applications serving as cell-sheet carriers, bio-adhesives and bio-artificial grafts. These different applications naturally have diverse physical, chemical and biological requirements and this has prompted research into the modification of gelatin and its derivatives. The crosslinking of gelatin alone or in combination with natural or synthetic biopolymers has produced a variety of scaffolds that could be suitable for ocular applications. This review focuses on methods to crosslink gelatin-based materials and how the resulting materials have been applied in ocular tissue engineering. Critical discussion of recent innovations in tissue engineering and regenerative medicine will highlight future opportunities for gelatin-based materials in ophthalmology.

Indexed as

biocompatibilitycorneagelatinophthalmologyretinal epitheliumtissue engineering

Identifiers

PMID28788609
PMCPMC5453355

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.