Evidence map›Paper›PMID 28788479›Full record

ArticleMaterials (Basel, Switzerland)2014

Karla Lehle, Jing Li, Hanngörg Zimmermann, Björn Hartmann, Daniel Wehner, Thomas Schmid, Christof Schmid

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Karla LehleDepartment of Cardiothoracic Surgery, University Medical Centre Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany. karla.lehle@ukr.de.
Jing LiDepartment of Cardiothoracic Surgery, University Medical Centre Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany. jing.li@ukr.de.
Hanngörg ZimmermannPFM medical titanium, Höfener Str. 45, 90431 Nürnberg, Germany. hanngoerg.zimmermann@pfmmedical.com.
Björn HartmannPFM medical titanium, Höfener Str. 45, 90431 Nürnberg, Germany. bjoern.hartmann@pfmmedical.com.
Daniel WehnerDualis Medtech GmbH, Am Technologiepark 8+10, 82229 Seefeld, Germany. daniel.wehner@dualis-medtech.de.
Thomas SchmidDualis Medtech GmbH, Am Technologiepark 8+10, 82229 Seefeld, Germany. thomas.schmid@hotmail.de.
Christof SchmidDepartment of Cardiothoracic Surgery, University Medical Centre Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany. christof.schmid@ukr.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycarbonateurethanes (PCU) and polyetherurethanes (PEU) are used for medical devices, however their bio- and haemocompatibility is limited. In this study, the effect of titaniferous upgrading of different polyurethanes on the bio- and haemocompatibility was investigated by endothelial cell (EC) adhesion/proliferation and platelet adhesion (scanning electron microscopy), respectively. There was no EC adhesion/proliferation and only minor platelet adhesion on upgraded and pure PCU (Desmopan). PEUs (Texin 985, Tecothane 1085, Elastollan 1180A) differed in their cyto- and haemocompatibility. While EC adhesion depended on the type of PEU, any proliferative activity was inhibited. Additional titaniferous upgrading of PEU induced EC proliferation and increased metabolic activity. However, adherent ECs were significantly activated. While Texin was highly thrombotic, only small amounts of platelets adhered onto Tecothane and Elastollan. Additional titaniferous upgrading reduced thrombogenicity of Texin, preserved haemocompatibility of Elastollan, and increased platelet activation/aggregation on Tecothane. In conclusion, none of the PUs was cytocompatible; only titaniferous upgrading allowed EC proliferation and metabolism on PEUs. Haemocompatibility depended on the type of PU.

Indexed as

cardiovascular tissue engineeringcytocompatibilityendothelial cell seedinghaemocompatibilityplatelet adhesiontitanium

Identifiers

PMID28788479
PMCPMC5453079

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.