ReviewMaterials (Basel, Switzerland)2013
On the Role of Mechanics in Chronic Lung Disease.
Review in Materials (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Efficacy of Physiotherapy Interventions on Weaning in Mechanically Ventilated Critically Ill Patients: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Morphometric analysis of airways in pre-COPD and mild COPD lungs using continuous surface representations of the bronchial lumen.Frontiers in bioengineering and biotechnology · 2023Article
- Mouse lung mechanical properties under varying inflation volumes and cycling frequencies.Scientific reports · 2022Article
- Examining lung mechanical strains as influenced by breathing volumes and rates using experimental digital image correlation.Respiratory research · 2022Article
- Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements.Materials (Basel, Switzerland) · 2021Article
- Developing a Lung Model in the Age of COVID-19: A Digital Image Correlation and Inverse Finite Element Analysis Framework.Frontiers in bioengineering and biotechnology · 2021Review
- Introducing a Custom-Designed Volume-Pressure Machine for Novel Measurements of Whole Lung Organ Viscoelasticity and Direct Comparisons Between Positive- and Negative-Pressure Ventilation.Frontiers in bioengineering and biotechnology · 2020Article
- Novel Mechanical Strain Characterization of VentilatedFrontiers in physiology · 2020Article
- Mechanics of pulmonary airways: Linking structure to function through constitutive modeling, biochemistry, and histology.Acta biomaterialia · 2019Article
- A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling.Biomechanics and modeling in mechanobiology · 2018Article
- The origin of compression influences geometric instabilities in bilayers.Proceedings. Mathematical, physical, and engineering sciences · 2018Article
- Elastosis during airway wall remodeling explains multiple co-existing instability patterns.Journal of theoretical biology · 2016Article
- Patient-Specific Airway Wall Remodeling in Chronic Lung Disease.Annals of biomedical engineering · 2015Article
- The role of mechanics during brain development.Journal of the mechanics and physics of solids · 2014Article
- A mechanical model predicts morphological abnormalities in the developing human brain.Scientific reports · 2014Article
- Period-doubling and period-tripling in growing bilayered systems.Philosophical magazine (Abingdon, England)Article
- Systems biology and mechanics of growth.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Progressive airflow obstruction is a classical hallmark of chronic lung disease, affecting more than one fourth of the adult population. As the disease progresses, the inner layer of the airway wall grows, folds inwards, and narrows the lumen. The critical failure conditions for airway folding have been studied intensely for idealized circular cross-sections. However, the role of airway branching during this process is unknown. Here, we show that the geometry of the bronchial tree plays a crucial role in chronic airway obstruction and that critical failure conditions vary significantly along a branching airway segment. We perform systematic parametric studies for varying airway cross-sections using a computational model for mucosal thickening based on the theory of finite growth. Our simulations indicate that smaller airways are at a higher risk of narrowing than larger airways and that regions away from a branch narrow more drastically than regions close to a branch. These results agree with clinical observations and could help explain the underlying mechanisms of progressive airway obstruction. Understanding growth-induced instabilities in constrained geometries has immediate biomedical applications beyond asthma and chronic bronchitis in the diagnostics and treatment of chronic gastritis, obstructive sleep apnea and breast cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.