Evidence map›Paper›PMID 28788083›Full record

ReviewInternational journal of molecular sciences2017

The HGF/SF Mouse Model of UV-Induced Melanoma as an In Vivo Sensor for Metastasis-Regulating Gene.

M Kathryn Leonard, Nidhi Pamidimukkala, Gemma S Puts, Devin E Snyder, Andrzej T Slominski, David M Kaetzel

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

M Kathryn LeonardDepartment of Biochemistry and Molecular Biology, School of Medicine, University of Maryland-Baltimore, Baltimore, MD 21201, USA. KLeonard@som.umaryland.edu.
Nidhi PamidimukkalaDepartment of Biochemistry and Molecular Biology, School of Medicine, University of Maryland-Baltimore, Baltimore, MD 21201, USA. NPamidi@umaryland.edu.
Gemma S PutsDepartment of Biochemistry and Molecular Biology, School of Medicine, University of Maryland-Baltimore, Baltimore, MD 21201, USA. GCook@som.umaryland.edu.
Devin E SnyderDepartment of Biochemistry and Molecular Biology, School of Medicine, University of Maryland-Baltimore, Baltimore, MD 21201, USA. Devin.Sharp@som.umaryland.edu.
Andrzej T SlominskiDepartment of Dermatology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35249, USA. aslominski@uabmc.edu.
David M KaetzelDepartment of Biochemistry and Molecular Biology, School of Medicine, University of Maryland-Baltimore, Baltimore, MD 21201, USA. DKaetzel@som.umaryland.edu.
University of Maryland, Baltimore · USUniversity of Alabama at Birmingham · US

Funding

EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9M
Suppression of Melanoma Initiation and Progression by NM23-H1R01CA159871 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI KAETZEL, DAVID M · 2012 to 2016
$2.2M
NM23 PROTEINS AND MECHANISMS OF PDGF A CHAIN SILENCINGR01CA083237 · NCI · UNIVERSITY OF KENTUCKY · PI KAETZEL, DAVID M · 1999 to 2010
$1.9M
NCI NIH HHS R01 CA083237NCI NIH HHS R01 CA159871NIGMS NIH HHS R25 GM055036
6 · The paper itself

Abstract

Cutaneous malignant melanoma is an aggressive and potentially lethal form of skin cancer, particularly in its advanced and therapy-resistant stages, and the need for novel therapeutics and prognostic tools is acute. Incidence of melanoma has steadily increased over the past few decades, with exposure to the genome-damaging effects of ultraviolet radiation (UVR) well-recognized as a primary cause. A number of genetically-engineered mouse models (GEMMs) have been created that exhibit high incidence of spontaneous and induced forms of melanoma, and a select subset recapitulates its progression to aggressive and metastatic forms. These GEMMs hold considerable promise for providing insights into advanced stages of melanoma, such as potential therapeutic targets and prognostic markers, and as in vivo systems for testing of novel therapies. In this review, we summarize how the HGF/SF transgenic mouse has been used to reveal metastasis-regulating activity of four different genes (

Indexed as

Gene Expression Regulation, NeoplasticAnimalsBiomarkers, TumorDisease Models, AnimalGene Expression ProfilingHepatocyte Growth FactorHumansMelanomaMiceMice, TransgenicNeoplasm MetastasisReproducibility of ResultsUltraviolet RaysBiomarkers, TumorHepatocyte Growth Factorgenetically engineered mouse modelsHGFmelanomametastasis

Identifiers

PMID28788083
PMCPMC5578037
OpenAlexW2741771458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.