ArticleMaterials (Basel, Switzerland)2015
Collagen Fibrils in Skin Orient in the Direction of Applied Uniaxial Load in Proportion to Stress while Exhibiting Differential Strains around Hair Follicles.
Article in Materials (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- A Device for Characterizing Skin Physiological Response to Mechanical Loading in Transtibial Prosthesis Users.Sensors (Basel, Switzerland) · 2026Article
- TowardFrontiers in bioengineering and biotechnology · 2026Review
- Collagen organization and structure inBiomedical optics express · 2024Article
- Collagen organization and structure inbioRxiv : the preprint server for biology · 2024Article
- Development of a facile method to compute collagen network pathological anisotropy using AFM imaging.Scientific reports · 2023Article
- An in-House System for the Precise Measurement of Electrical Potentials and Mechanical Properties of Soft Tissues: Design and Validation Using Adult Mammalian Tendon Fascicle Bundles.Materials (Basel, Switzerland) · 2022Article
- A method to analyze the influence of mechanical strain on dermal collagen morphologies.Scientific reports · 2021Article
- The heterogeneous morphology of networked collagen in distal colon and rectum of mice quantified via nonlinear microscopy.Journal of the mechanical behavior of biomedical materials · 2021Article
- General method for classification of fiber families in fiber-reinforced materials: application to in-vivo human skin images.Scientific reports · 2020Article
- Article
- Micropatterned cell sheets as structural building blocks for biomimetic vascular patches.Biomaterials · 2018Article
- How aging impacts skin biomechanics: a multiscale study in mice.Scientific reports · 2017Article
- General theory of skin reinforcement.PloS one · 2017Article
- Tension tests on mammalian collagen fibrils.Interface focus · 2016Article
- Ex vivo multiscale quantitation of skin biomechanics in wild-type and genetically-modified mice using multiphoton microscopy.Scientific reports · 2015Article
- Mechanics of Biological Tissues and Biomaterials: Current Trends.Materials (Basel, Switzerland) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We determined inhomogeneity of strains around discontinuities as well as changes in orientation of collagen fibrils under applied load in skin. Second Harmonic Generation (SHG) images of collagen fibrils were obtained at different strain magnitudes. Changes in collagen orientation were analyzed using Fast Fourier Transforms (FFT) while strain inhomogeneity was determined at different distances from hair follicles using Digital Image Correlation (DIC). A parameter, defined as the Collagen Orientation Index (COI), is introduced that accounts for the increasingly ellipsoidal nature of the FFT amplitude images upon loading. We show that the COI demonstrates two distinct mechanical regimes, one at low strains (0%, 2.5%, 5% strain) in which randomly oriented collagen fibrils align in the direction of applied deformation. In the second regime, beginning at 5% strain, collagen fibrils elongate in response to applied deformation. Furthermore, the COI is also found to be linearly correlated with the applied stress indicating that collagen fibrils orient to take the applied load. DIC results indicated that major principal strains were found to increase with increased load at all locations. In contrast, minimum principal strain was dependent on distance from hair follicles. These findings are significant because global and local changes in collagen deformations are expected to be changed by disease, and could affect stem cell populations surrounding hair follicles, including mesenchymal stem cells within the outer root sheath.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.