ArticleMolecular microbiology2017
ALBA4 modulates its stage-specific interactions and specific mRNA fates during Plasmodium yoelii growth and transmission.
Article in Molecular microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
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- Widespread release of translational repression across Plasmodium's host-to-vector transmission event.PLoS pathogens · 2025Article
- The DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum.Nature communications · 2024Article
- Global Release of Translational Repression AcrossbioRxiv : the preprint server for biology · 2024Article
- Nonsense-mediated decay machinery inmSphere · 2023Article
- Long-Read Genome Assembly and Gene Model Annotations for the Rodent Malaria ParasitebioRxiv : the preprint server for biology · 2023Article
- Article
- Standard Selection Treatments with Sulfadiazine Limit Plasmodium yoelii Host-to-Vector Transmission.mSphere · 2022Article
- Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum.PloS one · 2022Article
- The Plasmodium NOT1-G paralogue is an essential regulator of sexual stage maturation and parasite transmission.PLoS biology · 2021Article
- Phage Display Screening for Alba Superfamily Proteins from the Human Malaria Parasite, Plasmodium falciparum Reveals a High Level of Association with Protein Modification Pathways and Hints at New Drug Targets.Acta parasitologica · 2021Article
- Roles and Cellular Localization of GBP2 and NAB2 During the Blood Stage of Malaria Parasites.Frontiers in cellular and infection microbiology · 2021Article
- An Alba-domain protein required for proteome remodelling during trypanosome differentiation and host transition.PLoS pathogens · 2021Article
- Identification of Three NovelFrontiers in cellular and infection microbiology · 2021Article
- Definition of constitutive and stage-enriched promoters in the rodent malaria parasite, Plasmodium yoelii.Malaria journal · 2020Article
- Plasmodium berghei Gamete Egress Protein is required for fertility of both genders.MicrobiologyOpen · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Transmission of the malaria parasite occurs in an unpredictable moment, when a mosquito takes a blood meal. Plasmodium has therefore evolved strategies to prepare for transmission, including translationally repressing and protecting mRNAs needed to establish the infection. However, mechanisms underlying these critical controls are not well understood, including whether Plasmodium changes its translationally repressive complexes and mRNA targets in different stages. Efforts to understand this have been stymied by severe technical limitations due to substantial mosquito contamination of samples. Here using P. yoelii, for the first time we provide a proteomic comparison of a protein complex across asexual blood, sexual and sporozoite stages, along with a transcriptomic comparison of the mRNAs that are affected in these stages. We find that the Apicomplexan-specific ALBA4 RNA-binding protein acts to regulate development of the parasite's transmission stages, and that ALBA4 associates with both stage-specific and stage-independent partners to produce opposing mRNA fates. These efforts expand our understanding and ability to interrogate both sexual and sporozoite transmission stages and the molecular preparations they evolved to perpetuate their infectious cycle.
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