ArticleJournal of biomechanical engineering2017
Finite Element Biomechanics of Optic Nerve Sheath Traction in Adduction.
Article in Journal of biomechanical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 64 citations in OpenAlex.
- Optic Disc and Retinal Strain Due to Vertical Duction.Investigative ophthalmology & visual science · 2026Article
- Impact of Optic Nerve Tortuosity, Globe Proptosis, and Size on Retinal Ganglion Cell Thickness Across General, Glaucoma, and Myopic Populations.Investigative ophthalmology & visual science · 2025Article
- The association between asymmetric stress distribution on the lamina cribrosa and glaucoma progression.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Horizontal Gaze Tolerance and Its Effects on Visual Sensitivity in Glaucoma.Investigative ophthalmology & visual science · 2025Article
- Tensile properties of glaucomatous human sclera, optic nerve, and optic nerve sheath.Biomechanics and modeling in mechanobiology · 2024Article
- Effect of Eye Globe and Optic Nerve Morphologies on Gaze-Induced Optic Nerve Head Deformations.Investigative ophthalmology & visual science · 2024Article
- Postmortem Digital Image Correlation and Finite Element Modeling Demonstrate Posterior Scleral Deformations during Optic Nerve Adduction Tethering.Bioengineering (Basel, Switzerland) · 2024Article
- Optic Nerve Head Pulsatile Displacement in Open-Angle Glaucoma after Intraocular Pressure Reduction Measured by Optical Coherence Tomography: A Pilot Study.Bioengineering (Basel, Switzerland) · 2024Article
- Scanning Laser Ophthalmoscopy Demonstrates Pediatric Optic Disc and Peripapillary Strain During Horizontal Eye Rotation.Current eye research · 2024Article
- Changes in Optic Nerve Head Blood Flow During Horizontal Ocular Duction.Investigative ophthalmology & visual science · 2024Article
- Scanning Laser Ophthalmoscopy Demonstrates Disc and Peripapillary Strain During Horizontal Eye Rotation in Adults.American journal of ophthalmology · 2023Article
- Empirical Quantification of Optic Nerve Strain Due to Horizontal Duction.Bioengineering (Basel, Switzerland) · 2023Article
- Optical Coherence Tomography Angiography Demonstrates Strain and Volume Effects on Optic Disk and Peripapillary Vasculature Caused by Horizontal Duction.Current eye research · 2023Article
- Article
- Mapping Pulsatile Optic Nerve Head Deformation Using OCT.Ophthalmology science · 2022Article
- Finite element modeling of effects of tissue property variation on human optic nerve tethering during adduction.Scientific reports · 2022Article
- A minimal model of elastic instabilities in biological filament bundles.Journal of the Royal Society, Interface · 2022Article
- Computational Modeling of Ophthalmic Procedures: Computational Modeling of Ophthalmic Procedures.American journal of ophthalmology · 2022Article
- Biomechanical analysis of ocular diseases and its in vitro study methods.Biomedical engineering online · 2022Review
- Electrophysiological, biomechanical, and finite element analysis study of sacral nerve injury caused by sacral fracture.Frontiers in bioengineering and biotechnology · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Historical emphasis on increased intraocular pressure (IOP) in the pathogenesis of glaucoma has been challenged by the recognition that many patients lack abnormally elevated IOP. We employed finite element analysis (FEA) to infer contribution to optic neuropathy from tractional deformation of the optic nerve head (ONH) and lamina cribrosa (LC) by extraocular muscle (EOM) counterforce exerted when optic nerve (ON) redundancy becomes exhausted in adduction. We characterized assumed isotropic Young's modulus of fresh adult bovine ON, ON sheath, and peripapillary and peripheral sclera by tensile elongation in arbitrary orientations of five specimens of each tissue to failure under physiological temperature and humidity. Physical dimensions of the FEA were scaled to human histological and magnetic resonance imaging (MRI) data and used to predict stress and strain during adduction 6 deg beyond ON straightening at multiple levels of IOP. Young's modulus of ON sheath of 44.6 ± 5.6 MPa (standard error of mean) greatly exceeded that of ON at 5.2 ± 0.4 MPa, peripapillary sclera at 5.5 ± 0.8 MPa, and peripheral sclera at 14.0 ± 2.3 MPa. FEA indicated that adduction induced maximum stress and strain in the temporal ONH. In the temporal LC, the maximum stress was 180 kPa, and the maximum strain was ninefold larger than produced by IOP elevation to 45 mm Hg. The simulation suggests that ON sheath traction by adduction concentrates far greater mechanical stress and strain in the ONH region than does elevated IOP, supporting the novel concept that glaucomatous optic neuropathy may result at least partly from external traction on the ON, rather than exclusively on pressure on the ON exerted from within the eye.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.