SynthesisPloS one2017
Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- The effect of xylitol chewing gums and candies on caries occurrence in children: a systematic review with special reference to caries level at study baseline.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Pooled it
- Effects of sugar-free polyol chewing gums on gingival inflammation: a systematic review.Clinical oral investigations · 2022Pooled it
- Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2021Pooled it
- Evaluation of the alkaline water effect on the salivary bacteria of children: preliminary randomized trial.Scientific reports · 2026Trial
- Fluoride-Free Toothpastes for Caries Prevention: A Systematic Review of Clinical Evidence on Active Ingredients.Clinical, cosmetic and investigational dentistry · 2026Review
- Enhanced dominance of nitrate-reducing bacteria using a combination of nitrate and erythritol inJournal of oral microbiology · 2025Article
- Cariostatic Agents: From Silver Diamine Fluoride to Emerging Bioactive Compounds.Clinical, cosmetic and investigational dentistry · 2025Review
- The damage and remineralization strategies of dental hard tissues following radiotherapy.BMC oral health · 2024Article
- White Spot Lesions in Fixed Orthodontics: A Literature Review on Etiology, Prevention, and Treatment.Cureus · 2024Review
- Preparation and characterization of a nanohydroxyapatite and sodium fluoride loaded chitosan-basedHeliyon · 2024Article
- Revisiting Oral Antiseptics, Microorganism Targets and Effectiveness.Journal of personalized medicine · 2023Review
- Expert consensus on clinical management for early childhood caries.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Comparison of the effect of fluoride gel and two toothpastes with different materials on remineralization of initial carious lesions in primary teeth.Journal of family medicine and primary care · 2021Article
- Comparative Evaluation of Antibacterial Effect of Propolis and Aloe Vera, Xylitol, and Cpp-Acp Gels onInternational journal of dentistry · 2021Article
- Current uses of chlorhexidine for management of oral disease: a narrative review.Journal of dentistry · 2020Review
- Repurposing Napabucasin as an Antimicrobial Agent against Oral Streptococcal Biofilms.BioMed research international · 2020Article
- Spontaneously Arising Streptococcus mutans Variants with Reduced Susceptibility to Chlorhexidine Display Genetic Defects and Diminished Fitness.Antimicrobial agents and chemotherapy · 2019Article
- Antimicrobial efficacy of alternative compounds for use in oral care toward biofilms from caries-associated bacteria in vitro.MicrobiologyOpen · 2019Article
- The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products.International journal of molecular sciences · 2019Review
- State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management.Caries research · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the effect of non-fluoride agents on the prevention of dental caries in primary dentition. MATERIALS AND
methodsMedline, Web of Science, Embase, Cochrane Library, CBM and CNKI databases were searched to identify all the relevant articles published prior to 16 December 2016. Grey literature was also searched. Randomized controlled human clinical trials in which non-fluoride agents were delivered by any method were considered.
resultsOf the 1,236 studies screened, 39 full articles were scrutinized and 14 selected for inclusion in the final sample. Five chemical agents, namely arginine, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), chlorhexidine, triclosan and xylitol were investigated in these included studies. The cariostatic effects of non-fluoride agents in vivo were evaluated in comparison with fluoride or placebos in randomized controlled trials. There is evidence that the use of certain doses of xylitol may be effective in arresting dental caries in primary dentition. However, quantitative synthesis could not be carried out because of the clinical and methodological heterogeneity of the included studies.
conclusionsA study at low risk of bias indicated that daily use of xylitol wipes is a useful adjunct for caries control in young children, however, this conclusion should be interpreted with caution as this study had a very limited sample size. Chlorhexidine and CPP-ACP may be more effective than a placebo in managing caries in primary dentition, but their effectiveness is borderline when compared with fluoride. Arginine-containing mint confection and 0.3% triclosan varnish were found to reduce caries development in primary teeth but the evidence was at high risk of bias. High quality randomized controlled trials are needed in order to make a conclusive recommendation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.