Evidence map›Paper›PMID 28787429›Full record

ArticleBritish journal of cancer2017

Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform.

Gilberto S Almeida, Rafal Panek, Albert Hallsworth, Hannah Webber, Efthymia Papaevangelou, Jessica Kr Boult, Yann Jamin, Louis Chesler, Simon P Robinson

Open access · hybridAbstract readEvaluation Study
In one paragraph

Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Preclinical Applications of Magnetic Resonance Imaging in Oncology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  3. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Gilberto S AlmeidaDivision of Radiotherapy &Imaging, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
Rafal PanekDivision of Radiotherapy &Imaging, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
Albert HallsworthDivision of Clinical Studies, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.
Hannah WebberDivision of Clinical Studies, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.
Efthymia PapaevangelouDivision of Radiotherapy &Imaging, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
Jessica Kr BoultDivision of Radiotherapy &Imaging, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
Yann JaminDivision of Radiotherapy &Imaging, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
Louis CheslerDivision of Clinical Studies, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.
Simon P RobinsonDivision of Radiotherapy &Imaging, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
Institute of Cancer Research · GB

Funding

Cancer Research UK 18339Wellcome Trust
6 · The paper itself

Abstract

backgroundThe use of clinical MRI scanners to conduct pre-clinical research facilitates comparisons with clinical studies. Here the utility and sensitivity of anatomical and functional MRI data/biomarkers acquired from transgenic mouse models of neuroblastoma using a dedicated radiofrequency (RF) coil on a clinical 3T scanner was evaluated.

methodsMultiparametric MRI of transgenic mice bearing abdominal neuroblastomas was performed at 3T, and data cross-referenced to that acquired from the same mice on a pre-clinical 7T MRI system. T

resultsExcellent T

conclusionsSimultaneous multiparametric MRI of multiple tumour-bearing animals using this coil arrangement at 3T can provide high efficiency/throughput for both phenotypic characterisation and evaluation of novel therapeutics, and facilitate the introduction of functional MRI biomarkers into aligned imaging-embedded clinical trials.

Indexed as

MagnetsAnaplastic Lymphoma KinaseAnilidesAnimalsAntineoplastic AgentsContrast MediaCyclophosphamideDisease Models, AnimalFemaleMagnetic Resonance ImagingMaleMiceMice, TransgenicMutationNeuroblastomaN-Myc Proto-Oncogene ProteinAlk protein, mouseAnaplastic Lymphoma KinaseAnilidesAntineoplastic AgentscabozantinibContrast MediaCyclophosphamideMYCN protein, mouseN-Myc Proto-Oncogene ProteinPyridinesReceptor Protein-Tyrosine Kinases

Identifiers

PMID28787429
PMCPMC5589996
OpenAlexW2743111149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.