ReviewNature reviews. Immunology2017
Mechanisms and consequences of diversity-generating immune strategies.
Review in Nature reviews. Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- A potential antibody repertoire diversification mechanism through tyrosine sulfation for biotherapeutics engineering and production.Frontiers in immunology · 2022Pooled it
- Large-scale duplication events underpin population-level flexibility in tRNA gene copy number in Pseudomonas fluorescens SBW25.Nucleic acids research · 2024Article
- Trade-offs between receptor modification and fitness drive host-bacteriophage co-evolution leading to phage extinction or co-existence.The ISME journal · 2024Article
- Putting theory to the test: An integrated computational/experimental chemostat model of the tragedy of the commons.PloS one · 2024Article
- Phenotype Design Space Provides a Mechanistic Framework Relating Molecular Parameters to Phenotype Diversity Available for Selection.Journal of molecular evolution · 2023Article
- Landscape of immunoglobulin heavy chain γ gene class switch recombination in patients with adult T-cell leukemia-lymphoma.Haematologica · 2023Article
- Article
- A genome-wide association study of the occurrence of genetic variations in Edwardsiella piscicida, Vibrio harveyi, and Streptococcus parauberis under stressed environments.Journal of fish diseases · 2022Article
- Horizontal transfer of a plasmid possessing mcr-1 marked with a single nucleotide mutation between Escherichia coli isolates from community residents.BMC research notes · 2022Article
- Article
- Article
- Breaking the law: unconventional strategies for antibody diversification.Nature reviews. Immunology · 2019Review
- The ecology and evolution of microbial CRISPR-Cas adaptive immune systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- The effect of bacterial mutation rate on the evolution of CRISPR-Cas adaptive immunity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- CRISPR-Cas immunity leads to a coevolutionary arms race between Streptococcus thermophilus and lytic phage.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- CRISPR evolution and bacteriophage persistence in the context of population bottlenecks.RNA biology · 2019Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Species from all five kingdoms of life have evolved sophisticated mechanisms to generate diversity in genes that are involved in host-pathogen interactions, conferring reduced levels of parasitism to both individuals and populations. Here, we highlight unifying concepts that underpin these evolutionarily unrelated diversity-generating mechanisms (DGMs). We discuss the mechanisms of and selective forces acting on these diversity-generating immune strategies, as well as their epidemiological and co-evolutionary consequences. We propose that DGMs can be broadly classified into two classes - targeted and untargeted DGMs - which generate different levels of diversity with important consequences for host-parasite co-evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.