Evidence map›Paper›PMID 28786976›Full record

ArticleTranslational psychiatry2017

Neuronal-expressed microRNA-targeted pseudogenes compete with coding genes in the human brain.

S Barbash, A Simchovitz, A S Buchman, D A Bennett, S Shifman, H Soreq

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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  15. Religious Orders Study and Rush Memory and Aging Project.Journal of Alzheimer's disease : JAD · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

S BarbashThe Edmond &Lily Safra Center for Brain Sciences and the Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel.
A SimchovitzThe Edmond &Lily Safra Center for Brain Sciences and the Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel.
A S BuchmanRush Alzheimer's Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
D A BennettRush Alzheimer's Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
S ShifmanDepartment of Genetics, The Hebrew University of Jerusalem, Jerusalem, Israel.
H SoreqThe Edmond &Lily Safra Center for Brain Sciences and the Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel.
Hebrew University of Jerusalem · ILRush University Medical Center · US

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
Risk Factors, Pathology, and Clinical Expressions of ADRF1AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2014 to 2014
$6.0M
Exploring the Role of the Brain Epigenome: Cognitive Decline and Life ExperiencesR01AG036042 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2009 to 2013
$4.1M
Diseases/function/self-health in risk indices for eldersR01AG023626 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI COVINSKY, KENNETH E. · 2004 to 2006
$852k
European Research Council 321501NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG023626NIA NIH HHS R01 AG036042NIA NIH HHS RF1 AG015819
6 · The paper itself

Abstract

MicroRNAs orchestrate brain functioning via interaction with microRNA recognition elements (MRE) on target transcripts. However, the global impact of potential competition on the microRNA pool between coding and non-coding brain transcripts that share MREs with them remains unexplored. Here we report that non-coding pseudogene transcripts carrying MREs (PSG

Indexed as

Alzheimer DiseaseBrainCognitive DysfunctionHumansMicroRNAsNeuronsPseudogenesRNA, MessengerMicroRNAsRNA, Messenger

Identifiers

PMID28786976
PMCPMC5611730
OpenAlexW2742838690

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.