Evidence map›Paper›PMID 28786932›Full record

ArticleInternational journal of environmental research and public health2017

Estimated Maternal Pesticide Exposure from Drinking Water and Heart Defects in Offspring.

Jihye Kim, Michael D Swartz, Peter H Langlois, Paul A Romitti, Peter Weyer, Laura E Mitchell, Thomas J Luben, Anushuya Ramakrishnan, Sadia Malik, Philip J Lupo and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Observational
  6. Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence.International journal of environmental research and public health · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 1 country.

Jihye KimDepartment of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA. Jihye.Kim416@gmail.com.
Michael D SwartzDepartment of Biostatistics, University of Texas School of Public Health, Houston, TX 77030, USA. Michael.D.Swartz@uth.tmc.edu.
Peter H LangloisBirth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX 78714, USA. peter.langlois@dshs.texas.gov.
Paul A RomittiDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. paul-romitti@uiowa.edu.
Peter WeyerCenter for Health Effects of Environmental Contamination, University of Iowa, Iowa City, IA 52242, USA. peter-weyer@uiowa.edu.
Laura E MitchellDepartment of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA. Laura.E.Mitchell@uth.tmc.edu.
Thomas J LubenNational Center for Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Luben.Tom@epa.gov.
Anushuya RamakrishnanCommunity Epidemiology and Health Planning Unit, Cook County Department of Public Health, Oak Forest Health Center, Oak Forest, IL 60452, USA. anushuyar@gmail.com.
Sadia MalikDepartment of Pediatrics, University of Texas, Southwestern, Dallas, TX 75390, USA. Sadia.Malik@UTSouthwestern.edu.
Philip J LupoDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. philip.lupo@bcm.edu.
Marcia L FeldkampDivision of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. Marcia.Feldkamp@hsc.utah.edu.
Robert E MeyerDivision of Public Health, Birth Defects Monitoring Program, State Center for Health Statistics, Raleigh, NC 27699, USA. robert.meyer@dhhs.nc.gov.
Jennifer J WinstonDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC 27599, USA. jen_winston@med.unc.edu.
Jennita ReefhuisNational Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GA 30329, USA. nzr5@cdc.gov.
Sarah J BlossomDepartment of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR 72202, USA. blossomsarah@uams.edu.
Erin BellDepartment of Environmental Health Sciences, University at Albany School of Public Health, Albany, NY 12144, USA. ebell@albany.edu.
A J AgopianDepartment of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA. A.J.Agopian@uth.tmc.edu.
National Birth Defects Prevention StudyBirth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX 78714, USA. Jihye.Kim416@gmail.com.
The University of Texas Health Science Center at Houston · USUniversity of Iowa · USArkansas Children's Hospital · USBaylor College of Medicine · USCook County Department of Public Health · USEnvironmental Protection Agency · USNational Center on Birth Defects and Developmental Disabilities · USNorth Carolina Division of Public Health · USSouthwestern Medical Center · USTexas Department of State Health Services · USUniversity at Albany, State University of New York · USUniversity of North Carolina at Chapel Hill · USUniversity of Utah · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Texas Center for Birth Defects Research and PreventionU01DD000494 · DD · TEXAS STATE DEPT OF HEALTH SERVICES · PI CANFIELD, MARK A · 2009 to 2013
$3.9M
Iowa CBDRP: Birth Defects Study To Evaluate Pregnancy exposureSU01DD001035 · DD · UNIVERSITY OF IOWA · PI ROMITTI, PAUL A · 2013 to 2017
$3.5M
Pesticides in tap water and congenital heart defectsR21ES024895 · NIEHS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI AGOPIAN, A.J. · 2015 to 2016
$436k
NCBDD CDC HHS U01 DD000494NCBDD CDC HHS U01 DD001035NICHD NIH HHS P2C HD050924NIEHS NIH HHS P30 ES005605NIEHS NIH HHS R21 ES024895
6 · The paper itself

Abstract

Our objective was to examine the relationship between estimated maternal exposure to pesticides in public drinking water and the risk of congenital heart defects (CHD). We used mixed-effects logistic regression to analyze data from 18,291 nonsyndromic cases with heart defects from the Texas Birth Defects Registry and 4414 randomly-selected controls delivered in Texas from 1999 through 2005. Water district-level pesticide exposure was estimated by linking each maternal residential address to the corresponding public water supply district's measured atrazine levels. We repeated analyses among independent subjects from the National Birth Defects Prevention Study (NBDPS) (1620 nonsyndromic cases with heart defects and 1335 controls delivered from 1999 through 2005). No positive associations were observed between high versus low atrazine level and eight CHD subtypes or all included heart defects combined. These findings should be interpreted with caution, in light of potential misclassification and relatively large proportions of subjects with missing atrazine data. Thus, more consistent and complete monitoring and reporting of drinking water contaminants will aid in better understanding the relationships between pesticide water contaminants and birth defects.

Indexed as

AdultCase-Control StudiesDrinking WaterFemaleHeart Defects, CongenitalHumansLogistic ModelsMaleMaternal ExposurePesticidesTexasWater PollutionWater SupplyDrinking WaterPesticidesbirth defectscongenital heart defectpesticidepublic drinking waterTexas

Identifiers

PMID28786932
PMCPMC5580593
OpenAlexW2744161189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.