Evidence map›Paper›PMID 28786402›Full record

ArticlePhysics in medicine and biology2017

Comparison of region-of-interest-averaged and pixel-averaged analysis of DCE-MRI data based on simulations and pre-clinical experiments.

Dianning He, Marta Zamora, Aytekin Oto, Gregory S Karczmar, Xiaobing Fan

Abstract readComparative Study
In one paragraph

Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Dianning HeSino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, People's Republic of China.
Marta ZamoraDepartment of Radiology, The University of Chicago, Chicago, IL 60637, United States of America.
Aytekin OtoDepartment of Radiology, The University of Chicago, Chicago, IL 60637, United States of America.
Gregory S KarczmarDepartment of Radiology, The University of Chicago, Chicago, IL 60637, United States of America.
Xiaobing FanDepartment of Radiology, The University of Chicago, Chicago, IL 60637, United States of America.
University of Chicago · US

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1M
Quantitative DCEMRI of Prostate Cancer Correlation with Gold StandardsR01CA172801 · NCI · UNIVERSITY OF CHICAGO · PI KARCZMAR, GREGORY S., OTO, AYTEKIN · 2013 to 2017
$2.3M
MRI of Early Non-invasive Rodent Mammary CancersR01CA133490 · NCI · UNIVERSITY OF CHICAGO · PI KARCZMAR, GREGORY S. · 2011 to 2015
$1.6M
NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA133490NCI NIH HHS R01 CA172801
6 · The paper itself

Abstract

Differences between region-of-interest (ROI) and pixel-by-pixel analysis of dynamic contrast enhanced (DCE) MRI data were investigated in this study with computer simulations and pre-clinical experiments. ROIs were simulated with 10, 50, 100, 200, 400, and 800 different pixels. For each pixel, a contrast agent concentration as a function of time, C(t), was calculated using the Tofts DCE-MRI model with randomly generated physiological parameters (K

Indexed as

AlgorithmsAnimalsComputer SimulationContrast MediaGadolinium DTPAMagnetic Resonance ImagingMaleProstatic NeoplasmsRatsSignal-To-Noise RatioContrast MediaGadolinium DTPA

Identifiers

PMID28786402
PMCPMC5736132
OpenAlexW2744689555

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.