Evidence map›Paper›PMID 28786349›Full record

ArticleCurrent cancer drug targets2018

Aldose Reductase Inhibitor, Fidarestat Prevents High-fat Diet-induced Intestinal Polyps in Apc

Ashish Saxena, Ravinder Tammali, Kota V Ramana, Satish K Srivastava

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current cancer drug targets, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ashish SaxenaDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Ravinder TammaliDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Kota V RamanaDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Satish K SrivastavaDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, United States.
The University of Texas Medical Branch at Galveston · US

Funding

Chemoprevention of Colorectal Cancer by Aldose Reductase InhibitionR01CA129383 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RAMANA, KOTA VENKATA · 2008 to 2017
$3.1M
Role of Aldose Reductase in Diabetic ComplicationsR01DK104786 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RAMANA, KOTA VENKATA · 2015 to 2019
$2.2M
NCI NIH HHS R01 CA129383NIDDK NIH HHS R01 DK104786
6 · The paper itself

Abstract

backgroundRecent epidemiological and experimental studies have shown that obesity is a major risk factor for Colorectal Cancer (CRC). Regular intake of high fat-containing diet can promote obesity and metabolic syndrome by increasing the insulin resistance and inflammatory response which contribute to carcinogenesis. Previously, we have shown that inhibition of polyol pathway enzyme aldose reductase (AR) prevents carcinogens- and inflammatory growth factorsinduced CRC. However, the effect of AR inhibition on a high-fat diet (HFD)-induced formation of intestinal polyps in Apc-deficient Min (multiple intestinal neoplasia; ApcMin/+) mice is not known.

methodsWe examined the effect of AR inhibitor, fidarestat on the HFD-induced formation of preneoplastic intestinal polyps in ApcMin/+ mice which is an excellent model of colon cancer.

resultsAPC

conclusionOur results thus suggest that fidarestat could be used as a potential chemopreventive drug for intestinal cancers due to APC gene mutations.

Indexed as

Adenomatous Polyposis Coli ProteinAldehyde ReductaseAnimalsColonic NeoplasmsDiet, High-FatEnzyme InhibitorsFemaleImidazolidinesIntestinal PolypsMaleMiceMice, Inbred C57BLAdenomatous Polyposis Coli Proteinadenomatous polyposis coli protein, mouseAldehyde ReductaseEnzyme InhibitorsfidarestatImidazolidinesAldose reductaseAPC Min micecolon cancerfidarestathigh-fat dietpolyps.

Identifiers

PMID28786349
PMCPMC5803460
OpenAlexW2743880280

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.