Evidence map›Paper›PMID 28785985›Full record

ArticlePediatric nephrology (Berlin, Germany)2018

A curious case of growth failure and hypercalcemia: Answers.

Mallory L Downie, Jaap Mulder, Rayfel Schneider, Lillian Lim, Nasrin Tehrani, Jonathan D Wasserman, Shai Fuchs, Rohan John, Damien G Noone, Diane Hebert

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Mallory L DownieDivision of Nephrology, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Jaap MulderDivision of Nephrology, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Rayfel SchneiderDivision of Rheumatology, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.
Lillian LimDivision of Rheumatology, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.
Nasrin TehraniDivision of Ophthalmology, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.
Jonathan D WassermanDivision of Endocrinology, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.
Shai FuchsDivision of Endocrinology, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.
Rohan JohnDepartment of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada.
Damien G NooneDivision of Nephrology, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Diane HebertDivision of Nephrology, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. diane.hebert@sickkids.ca.
University of Toronto · CAUniversity College London · GBGreat Ormond Street Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcoidosis is a multisystem granulomatous disease of unknown etiology that rarely presents in childhood. Here, we report a case of pediatric sarcoidosis, presenting with renal failure and hypercalcemia. CASE DIAGNOSIS/TREATMENT: A previously well 14-year-old Caucasian boy was admitted to the Hospital for Sick Children, Canada, for hypertension and renal failure following work-up by his family physician for initial concerns of growth failure. On admission, his weight was 35 kg (<3rd percentile), his height was 148 cm (<<3rd percentile), and his blood pressure was 154/116 mmHg (>99th percentile for height). Laboratory findings showed elevated creatinine (218 umol/L), hypercalcemia (3.21 mmol/L), and normocytic anemia (hemoglobin 105 g/L). His further assessment showed a urinary concentrating defect with hypercalciuria (calcium/creatinine 1.76 mmol/mmol) and nephrocalcinosis on ultrasound. His eye examination showed uveitis with conjunctival biopsy remarkable for granulomas, which led to pursuit of a diagnosis of possible sarcoidosis. Angiotensin Angiotensin-converting enzyme was found to be high at 96 U/L, and he had a renal biopsy that was consistent with interstitial nephritis with granulomas. Treatment was started with prednisone leading to resolution of his hypercalcemia but persistence of his mild chronic kidney disease.

conclusionsThis case represents an atypical presentation of a rare pediatric disease and highlights the spectrum of renal manifestations and treatment options in sarcoidosis.

Indexed as

AdolescentDiagnosis, DifferentialFailure to ThriveHumansHypercalcemiaKidneyMaleRenal InsufficiencySarcoidosisChildrenGranulomaHypercalcemiaPediatricRenal failureSarcoidosis

Identifiers

PMID28785985
OpenAlexW2742311167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.