Evidence map›Paper›PMID 28785937›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2017

Tobacco Use is a Modifiable Risk Factor for Post-Transplant Biliary Complications.

David T Dulaney, Katherine M Dokus, Scott McIntosh, Bandar Al-Judaibi, Gopal A Ramaraju, Koji Tomiyama, Mark Levstik, Roberto Hernandez-Alejandro, Mark S Orloff, Randeep Kashyap

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

David T DulaneyDivision of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave, Box SURG - TRANSPLANT, Rochester, NY, 14642, USA.ORCID http://orcid.org/0000-0001-9796-9982
Katherine M DokusDivision of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave, Box SURG - TRANSPLANT, Rochester, NY, 14642, USA.
Scott McIntoshDivision of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave, Box SURG - TRANSPLANT, Rochester, NY, 14642, USA.
Bandar Al-JudaibiDivision of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave, Box SURG - TRANSPLANT, Rochester, NY, 14642, USA.
Gopal A RamarajuDivision of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave, Box SURG - TRANSPLANT, Rochester, NY, 14642, USA.
Koji TomiyamaDivision of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave, Box SURG - TRANSPLANT, Rochester, NY, 14642, USA.
Mark LevstikDivision of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave, Box SURG - TRANSPLANT, Rochester, NY, 14642, USA.
Roberto Hernandez-AlejandroDivision of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave, Box SURG - TRANSPLANT, Rochester, NY, 14642, USA.
Mark S OrloffDivision of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave, Box SURG - TRANSPLANT, Rochester, NY, 14642, USA.
Randeep KashyapDivision of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave, Box SURG - TRANSPLANT, Rochester, NY, 14642, USA. randeep_kashyap@urmc.rochester.edu.
University of Rochester Medical Center · US

Funding

Web-Assisted Tobacco Intervention with Community College StudentsR01CA152093 · NCI · UNIVERSITY OF ROCHESTER · PI MCINTOSH, SCOTT · 2011 to 2015
$2.5M
NCI NIH HHS R01 CA152093New York State Department of Health (US) C029612
6 · The paper itself

Abstract

purposeBiliary complications following liver transplantation are a significant source of morbidity, potentially leading to graft failure necessitating retransplantation. We sought to evaluate smoking as an independent risk factor for post-transplant biliary complications.

methodsThe clinical course of all adult primary deceased donor liver transplants at our center from 1992 to 2012 was reviewed. Eligible patients were assigned to cohorts based on their lifetime tobacco exposure: never smokers indicating 0 pack-year exposure and all others were ever smokers. Biliary complications were defined as strictures, leaks, or bilomas requiring intervention. Complication rates were analyzed using univariate regression models correlated with donor and recipient characteristics. Associations found during univariate analysis were included in the final multivariate Cox model.

resultsEight hundred sixty-five subjects were followed for a median of 65 months; 482 (55.7%) of patients had a positive smoking history at the time of transplant. In univariate analysis, positive tobacco smoking history (HR = 1.36; p = 0.037) and increased time from quit date to transplantation (HR = 0.998; p = 0.011) were positive and negative predictors of biliary complication, respectively. Lifetime tobacco exposure remained a significant predictor of biliary complication on multivariate analysis (HR = 1.408; p = 0.023).

conclusionsSmoking status is an independent predictor of post-transplant biliary complications, and the data presented reinforces the importance of early smoking cessation in the pre-transplantation period.

Indexed as

Liver TransplantationAdolescentAdultAgedBiliary Tract DiseasesFemaleFollow-Up StudiesHumansMaleMiddle AgedPostoperative ComplicationsRegression AnalysisRetrospective StudiesRisk FactorsTobacco SmokingYoung AdultBilary leaksBiliary complicationsBilomaLiver transplantationSmokingStrictureTobacco

Identifiers

PMID28785937
OpenAlexW2743012035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.