Evidence map›Paper›PMID 28785911›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2018

Usefulness of lymphocyte-to-monocyte, neutrophil-to-monocyte and neutrophil-to-lymphocyte ratios as prognostic markers in breast cancer patients treated with neoadjuvant chemotherapy.

C Marín Hernández, A Piñero Madrona, P J Gil Vázquez, P J Galindo Fernández, G Ruiz Merino, J L Alonso Romero, P Parrilla Paricio

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In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04729647 (Immature Granulocyte Count and Delta Neutrophil Index as New Predictive Factors for Axillary Metastasis of Breast Cancer), which is not on this map. Cited by 67 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04729647 nacompletednot on this map

Immature Granulocyte Count and Delta Neutrophil Index as New Predictive Factors for Axillary Metastasis of Breast Cancer

TypeinterventionalSponsorKahramanmaras Sutcu Imam UniversityRan2015 to 2020Enrolled83ConditionsBreast Cancer, Breast Cancer InvasiveArmsMastectomy
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

C Marín HernándezBreast Unit, Service of General Surgery, University Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena s/n, 30120, Murcia, Spain. carikimh@gmail.com.ORCID http://orcid.org/0000-0002-1708-9166
A Piñero MadronaBreast Unit, Service of General Surgery, University Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena s/n, 30120, Murcia, Spain.
P J Gil VázquezBreast Unit, Service of General Surgery, University Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena s/n, 30120, Murcia, Spain.
P J Galindo FernándezBreast Unit, Service of General Surgery, University Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena s/n, 30120, Murcia, Spain.
G Ruiz MerinoBreast Unit, Service of General Surgery, University Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena s/n, 30120, Murcia, Spain.
J L Alonso RomeroBreast Unit, Service of General Surgery, University Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena s/n, 30120, Murcia, Spain.
P Parrilla ParicioBreast Unit, Service of General Surgery, University Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena s/n, 30120, Murcia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNowadays, neoadjuvant chemotherapy (nCT) in breast cancer is more and more standardized, not only in advanced tumours but also in those for which there is an attempt to achieve breast-conserving surgery. In literature, we can find evidences of the relationship between several types of tumours and systemic inflammatory response. Our objective is to analyse the prognostic value of blood parameters (lymphocytes, neutrophils, monocytes, lymphocyte-to-monocyte ratio (LMR), neutrophil-to-monocyte ratio (NMR) and neutrophil-to-lymphocyte ratio (NLR) in breast cancer (BC) patients treated with nCT.

methodsA retrospective cohort of 150 breast cancer patients treated with nCT and subsequently with surgery was analysed. Data about the patients, histology, response to chemotherapy and peripheral blood values of lymphocytes, monocytes and neutrophils was collected, and used to calculate the LMR, NMR and NLR. Univariate and multivariate analyses were performed for the variables to see the relationship of the ratios to disease-free survival (DFS) and overall survival (OS).

resultsPatients with high LMR (≥5.46) and low NLR (<3.33) were associated with a lower percentage of relapse (P = 0.048 and P = 0.015, respectively) and, above all, NLR was associated with a better survival (P = 0.024), being those factors that predict a good progress.

conclusionHigh LMR and low NLR can be considered as favourable prognostic factors in BC patients treated with nCT.

Indexed as

Neoadjuvant TherapyAdultAgedBiomarkers, TumorBreast NeoplasmsChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateLeukocyte CountMiddle AgedMonocytesNeutrophilsPrognosisProportional Hazards ModelsBiomarkers, TumorBreast cancerLymphocyte-to-monocyte ratioNeoadjuvant chemotherapyNeutrophil-to-lymphocyte ratioNeutrophil-to-monocyte ratio

Identifiers

PMID28785911

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.