ReviewMedical & biological engineering & computing2017
A review of computational models of bone fracture healing.
Review in Medical & biological engineering & computing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Patient-Specific Adaptation of a Mechano-Regulatory Bone-Healing Model Using Longitudinal Loading Data.Annals of biomedical engineering · 2026Article
- Application of axial load-share ratio testing technology in the bone transport treatment of large segmental tibial bone defects.BMC musculoskeletal disorders · 2026Article
- The Effect of Plate Working Length on Interfragmentary Movement in a Distal Femoral Fracture: A Biomechanical Study.Cureus · 2025Article
- Associations between an inflammatory diet index and nonunion: a prospective study of 172,839 UK biobank participants.Frontiers in nutrition · 2025Article
- Computational modelling of bone growth and mineralization surrounding biodegradable Mg-based and permanent Ti implants.Computational and structural biotechnology journal · 2025Article
- Biomechanics of Osseointegration of a Dental Implant in the Mandible Under Shock Wave Therapy: In Silico Study.Materials (Basel, Switzerland) · 2024Article
- Immunomodulation Pathogenesis and Treatment of Bone Nonunion.Orthopaedic surgery · 2024Review
- Case Studies of a Simulation Workflow to Improve Bone Healing Assessment in Impending Non-Unions.Journal of clinical medicine · 2024Article
- Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice.Calcified tissue international · 2022Article
- Article
- Design and Mechanical Properties Verification of Gradient Voronoi Scaffold for Bone Tissue Engineering.Micromachines · 2021Article
- Individualized Determination of the Mechanical Fracture Environment After Tibial Exchange Nailing-A Simulation-Based Feasibility Study.Frontiers in surgery · 2021Article
- [Numerical simulation of fracture healing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Are the Lives of Animals Well-spent in Laboratory Science Research? A Study of Orthopaedic Animal Studies in Turkey.Clinical orthopaedics and related research · 2020Review
- The biology and treatment of acute long-bones diaphyseal fractures: Overview of the current options for bone healing enhancement.Bone reports · 2020Review
- A methodology for the generation and non-destructive characterisation of transverse fractures in long bones.Bone reports · 2018Article
- Three-dimensional computational model simulating the fracture healing process with both biphasic poroelastic finite element analysis and fuzzy logic control.Scientific reports · 2018Article
- How can biological modeling help cell biology?Cellular logistics · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the process of fracture healing, there are many cellular and molecular events that are regulated by mechanical stimuli and biochemical signals. To explore the unknown mechanisms underlying bone fracture healing, optimal fixation configurations, and the design of new treatment strategies, computational healing models provide a good solution. With the simulation of mechanoregulatory healing models, bioregulatory healing models and coupled mechanobioregulatory healing models, healing outcomes can be predicted. In this review, first, we provide an overview of current computational healing models. Their clinical applications are also presented. Then, the limitations of current models and their corresponding solutions are discussed in this review. Finally, future potentials are presented in this review. Multiscale modeling from the intracellular level to the tissue level is essential, and more clinical applications of computational healing models are required in future research.
Indexed as
Identifiers
28785849What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.