ArticleJournal of genetic counseling2018
Blue Genes? Understanding and Mitigating Negative Consequences of Personalized Information about Genetic Risk for Depression.
Article in Journal of genetic counseling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03998748 (Electrophysiological Correlates of Cognition in Depression), which is not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electrophysiological Correlates of Cognition in Depression
Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Schoolhouse risk: Can we mitigate the polygenic Pygmalion effect?Acta psychologica · 2024Trial
- Limited impacts of biogenetic messaging on neural correlates of cognitive control and beliefs about depression.Cognitive, affective & behavioral neuroscience · 2023Trial
- Potential for Genomics to Help Guide Preventive Strategies in Psychiatry.JAMA psychiatry · 2026Article
- Effects of bogus genetic feedback on subjective and physiological responses to acute stress.Comprehensive psychoneuroendocrinology · 2026Article
- Viewing direct-to-consumer genetic test results for depression risk is psychologically well tolerated: Evidence from a longitudinal equivalence study.HGG advances · 2026Article
- Social and Behavioral Genomics: On the Ethics of the Research and Its Downstream Applications.Annual review of genomics and human genetics · 2025Review
- Implications of genetic attributions for addiction among addiction professionals.Journal of psychiatric research · 2024Article
- Psychiatric polygenic risk scores: Experience, hope for utility, and concerns among child and adolescent psychiatrists.Psychiatry research · 2024Article
- Tracing Tomorrow: young people's preferences and values related to use of personal sensing to predict mental health, using a digital game methodology.BMJ mental health · 2024Article
- Commentary: Perspectives on ADHD in children and adolescents as a social construct amidst rising prevalence of diagnosis and medication use.Frontiers in psychiatry · 2024Article
- The undue influence of genetic information on senior medical students' treatment decisions.BMC medical education · 2023Article
- Review
- Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians' attitudes to sociocultural differences between patients across the globe.Translational psychiatry · 2022Review
- Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits.The lancet. Psychiatry · 2022Review
- The symptom discounting effect: what to do when negative genetic test results become risk factors for alcohol use disorder.Scientific reports · 2022Article
- Genetics of substance use disorders: a review.Psychological medicine · 2021Article
- Relationships of biomedical beliefs about depression to treatment-related expectancies in a treatment-seeking sample.Psychotherapy (Chicago, Ill.) · 2021Article
- Perceptions of best practices for return of results in an international survey of psychiatric genetics researchers.European journal of human genetics : EJHG · 2021Article
- Pygmalion in the Genes? On the potentially negative impacts of polygenic scores for educational attainment.Social psychology of education : an international journal · 2021Article
- Genetic feedback for psychiatric conditions: Where are we now and where are we going.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Personalized genetic testing for vulnerability to mental disorders is expected to become increasingly common. It is therefore important to understand whether learning about one's genetic risk for a mental disorder has negative clinical implications, and if so, how these might be counteracted. Among participants with depressive symptoms, we administered a sham biochemical test purportedly revealing participants' level of genetic risk for major depression. Participants told that they carried a genetic predisposition to depression expressed significantly lower confidence in their ability to cope with depressive symptoms than participants told they did not carry this predisposition. A short intervention providing education about the non-deterministic nature of genes' effects on depression fully mitigated this negative effect, however. Given the clinical importance of patient expectancies in depression, the notion that pessimism about one's ability to overcome symptoms could be exacerbated by genetic information-which will likely become ever more widely available-represents cause for concern. Education and counseling about the malleability of genetic effects may be an important tool for counteracting clinically deleterious beliefs that can be evoked by genetic test results. Genetic counselors may be able to help patients avoid becoming demoralized by learning they have a genetic predisposition to depression by providing education about the non-deterministic role of biology in depression, and a brief audiovisual intervention appears to be an effective approach to delivering such education.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.