Evidence map›Paper›PMID 28785647›Full record

ArticleInternational journal of cardiology. Heart & vasculature2015

Etiology-specific assessment of predictors of long-term survival in chronic systolic heart failure.

Jennifer Franke, Christian Zugck, Matthias Hochadel, Anna Hack, Lutz Frankenstein, Jingting Désirée Zhao, Philipp Ehlermann, Manfred Nelles, Uwe Zeymer, Ralph Winkler and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jennifer FrankeDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany.
Christian ZugckDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany.
Matthias HochadelInstitut für Herzinfarktforschung at the University of Heidelberg, Ludwigshafen, Germany.
Anna HackDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany.
Lutz FrankensteinDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany.
Jingting Désirée ZhaoDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany.
Philipp EhlermannDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany.
Manfred NellesDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany.
Uwe ZeymerDepartment of Cardiology, Heart Center Ludwigshafen, Ludwigshafen, Germany.
Ralph WinklerDepartment of Cardiology, Heart Center Ludwigshafen, Ludwigshafen, Germany.
Ralf ZahnDepartment of Cardiology, Heart Center Ludwigshafen, Ludwigshafen, Germany.
Hugo A KatusDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany.
Jochen SengesInstitut für Herzinfarktforschung at the University of Heidelberg, Ludwigshafen, Germany.
Heidelberg University · DEKlinikum Ludwigshafen · DEStiftung Institut für Herzinfarktforschung · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe sought to identify prognostic factors of long-term mortality, specific for the underlying etiology of chronic systolic heart failure (CHF). METHODS AND

resultsBetween 1995 and 2009 baseline characteristics, treatment and follow-up data from 2318 CHF-patients due to ischemic (ICM; 1100 patients) or dilated cardiomyopathy (DCM; 1218 patients) were prospectively compared. To calculate hazard ratios with 95%-confidence intervals cox regression was used. We respectively established etiology-specific multivariable models of independent prognostic factors. During the follow-up period of up to 14.8 years (mean = 53.1 ± 43.5 months; 10,264 patient-years) 991 deaths (42.8%) occurred. In the ICM-cohort, 5-year-survival was 53.4% (95% CI: 49.9-56.7%), whereas in DCM-patients it was higher (68.1% (95% CI: 65.1-71.0%)). Age, ejection fraction, or hyponatremia were independent predictors for mortality in both cohorts, whereas diabetes, COPD, atrial fibrillation and a heart rate of ≥ 80/min carried independent predictive power only in ICM-patients.

conclusionThis study demonstrates the disparity of prognostic value of clinically derived risk factors between the two main causes of CHF. The effects of covariables in DCM-patients were lower, suggesting a less modifiable disease through risk factors considering mortality risk. An etiology-specific prognostic model may improve accuracy of survival estimations in CHF.

Indexed as

ACE-I, Angiotensin-converting enzyme inhibitorARB, Angiotensin receptor blockerBBL, Beta-blockersCHF, Chronic systolic heart failureCRT, Cardiac resynchronization therapy defibrillatorDCM, Dilated cardiomyopathyDilated cardiomyopathyEF, Left ventricular ejection fractionHeart failureHTX, Orthotopic heart transplantationICD, Implantable cardioverter-defibrillatorICM, Ischemic cardiomyopathyIschemic cardiomyopathyLBBB, Left bundle branch blockNT-proBNP, N-terminal pro-peptide of brain natriuretic peptideNYHA, New York Heart AssociationPrognosis

Identifiers

PMID28785647
PMCPMC5497234
OpenAlexW1999090065

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.