Evidence map›Paper›PMID 28785645›Full record

ArticleInternational journal of cardiology. Heart & vasculature2015

A cardioprotective insight of the cystathionine γ-lyase/hydrogen sulfide pathway.

Steve Huang, Hua Li, Junbo Ge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. Unravelling the Therapeutic Potential of Cysteine for Cardiovascular Health.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Comparative Study of Different HAntioxidants (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Homocysteinylation and Sulfhydration in Diseases.Current neuropharmacology · 2022
    Review
  8. Article
  9. Review
  10. HJournal of clinical medicine · 2021
    Article
  11. Article
  12. Trends in HAntioxidants (Basel, Switzerland) · 2021
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Steve HuangShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Hua LiShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Junbo GeShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
The First Affiliated Hospital, Sun Yat-sen University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditionally, hydrogen sulfide (H

Indexed as

Akt, protein kinase BAngiogenesisAtherosclerosisBCA, brachiocephalic arteryCAM, chorioallantoic membraneCAT, cysteine aminotransferaseCBS, cystathionine β-lyaseCLP, cecal ligation and punctureCSE, cystathionine γ-lyaseCSE KO, CSE knock outCTO, chronic total occlusionCX3CL1, chemokine (C-X3-C Motif) ligand 1CX3CR1, CX3C chemokine receptor 1Cystathionine γ-lyaseEC, endothelial cellERK, extracellular signal-regulated kinaseGAPDH, glyceraldehyde 3-phosphate dehydrogenaseGSH-Px, glutathione peroxidaseGYY4137, morpholin-4-Ium-4-methoxyphenyl(morpholino) phosphinodithioateH2S, hydrogen sulfideHUVECs, human umbilical vein endothelial cellsHydrogen sulfideICAM-1, inter cellular adhesion molecule-1IMT, intima–media complex thicknessIschemia–reperfusion injuryl-NAME, NG-nitro-l-arginine methyl esterLPS, lipopolysaccharideMAPK, mitogen-activated protein kinaseMPO, myeloperoxidaseMST, 3-mercaptopyruvate sulfurtransferaseNF-κB, nuclear factor kappa-light-chain-enhancer of activated B cellsNrf2, nuclear factor erythroid 2-related factor 2oxLDL, oxidized low density lipoproteinPAG, DL-propagylglycinePPAR-γ, peroxisome proliferator-activated receptorPTPN1, protein tyrosine phosphatase, non-receptor type 1ROS, reactive oxygen speciesSAH, S-adenosylhomocysteineSAM, S-adenosylmethionineS-diclofenac, 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid 4-(3H-1,2-dithiole-3-thione-5-Yl)-phenyl esterSMCs, smooth muscle cellsSOD, superoxide dismutaseVasorelaxationVEGF, vascular endothelial growth factorVSMCs, vascular smooth muscle cells

Identifiers

PMID28785645
PMCPMC5497180
OpenAlexW2120393208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.