ReviewJournal of ophthalmology2017
Vitreous Substitutes: Old and New Materials in Vitreoretinal Surgery.
Review in Journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Novel Vitreous Substitutes in Animal and Human Models: A Systematic Review.BioMed research international · 2026Pooled it
- Foldable capsular vitreous body indications, complications, and outcomes: a systematic review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Pooled it
- Effect of Anti-VEGF Therapy on the Disease Progression of Neovascular Age-Related Macular Degeneration: A Systematic Review and Model-Based Meta-Analysis.Journal of clinical pharmacology · 2022Pooled it
- Comparison of Viscoelastic Substance Injection Versus Air Filling in the Anterior Chamber During Foldable Capsular Vitreous Body (FCVB) Implant Surgery: A Prospective Randomized Controlled Trial.Advances in therapy · 2021Trial
- A four-year retrospective surgical case series examining postoperative complications following Removal of Silicone Oil (ROSO) scored using the Complications of Retinal Detachment Surgery (CORDS) severity classification tool.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Risk factors for early emulsification of silicone oil after surgery for rhegmatogenous retinal detachment.Indian journal of ophthalmology · 2026Observational
- Biocompatibility Assessment of Polydimethylsiloxane for Vitreous Substitution Application in Relation to Physicochemical Properties.Polymers · 2026Article
- Tailoring polymethylhydrosiloxane as candidate material for vitreous humour substitution: physical properties and in vitro toxicity.BMC chemistry · 2025Article
- Application of Silicone in Ophthalmology: A Review.Materials (Basel, Switzerland) · 2024Review
- Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications.Smart molecules : open access · 2024Review
- Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity.Journal of functional biomaterials · 2023Article
- Are all primary retinal detachments the same? Anatomic and functional differences between phakic and pseudophakic patients.International journal of retina and vitreous · 2023Article
- Advances in Polysaccharide- and Synthetic Polymer-Based Vitreous Substitutes.Pharmaceutics · 2023Review
- Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery.International journal of molecular sciences · 2023Review
- Vitreous humor proteome: unraveling the molecular mechanisms underlying proliferative and neovascular vitreoretinal diseases.Cellular and molecular life sciences : CMLS · 2022Review
- Study on the efficacy and safety of foldable capsular vitreous body in the severe retinal detachment eyes.BMC ophthalmology · 2022Article
- Advances in Vitreoretinal Surgery.Journal of clinical medicine · 2022Review
- Hyaluronic Acid: Its Versatile Use in Ocular Drug Delivery with a Specific Focus on Hyaluronic Acid-Based Polyelectrolyte Complexes.Pharmaceutics · 2022Review
- Clinical characteristics of primary pars plana vitrectomy combined with air filling for rhegmatogenous retinal detachment.Scientific reports · 2022Article
- Evaluation of Foldable Capsular Vitreous Body Implantation Surgery.International journal of general medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent developments in vitreoretinal surgery have increased the need for suitable vitreous substitutes. A successful substitute should maintain all the physical and biochemical properties of the original vitreous, be easy to manipulate, and be long lasting. Substitutes can be gaseous or liquid, both of which have associated advantages and disadvantages related to their physical properties and use. Furthermore, new surgical techniques with smaller vitreoretinal instruments have driven the use of more viscous substitutes. In this review, we analyze and discuss the most frequently used vitreous substitutes and look ahead to future alternatives. We classify these compounds based on their composition and structure, discuss their clinical use with respect to their associated advantages and disadvantages, and analyze how new vitreoretinal surgical techniques have modified their use.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.