ArticleCardiac failure review2017
Expert Comment: Is Medication Titration in Heart Failure too Complex?
Article in Cardiac failure review, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Non-invasive home telemonitoring in patients with decompensated heart failure: a systematic review and meta-analysis.ESC heart failure · 2021Pooled it
- Influence of diabetes on sacubitril/valsartan titration and clinical outcomes in patients hospitalized for heart failure.ESC heart failure · 2023Trial
- Collaborative pharmacist prescribing in community heart failure clinics: a pre-post intervention comparison.International journal of clinical pharmacy · 2026Observational
- Quality of Care among Post-discharge Patients with Heart Failure with Reduced Ejection Fraction (HFrEF) at the Outpatient Department (OPD) of a Tertiary Center.Acta medica Philippina · 2025Article
- Article
- A practical approach to the guideline-directed pharmacological treatment of heart failure with reduced ejection fraction.ESC heart failure · 2023Review
- Reduction of heart failure guideline-directed medication during hospitalization: prevalence, risk factors, and outcomes.ESC heart failure · 2022Article
- Article
- Population Pharmacokinetics of Candesartan in Patients with Chronic Heart Failure.Clinical and translational science · 2021Observational
- Article
- Impact of Remote Titration Combined With Telemonitoring on the Optimization of Guideline-Directed Medical Therapy for Patients With Heart Failure: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2020Article
- The art and science of drug titration.Therapeutic advances in drug safety · 2020Review
- Who approves/pays for additional monitoring?European heart journal supplements : journal of the European Society of Cardiology · 2019Article
- Utilization and Dose Optimization of Angiotensin-Converting Enzyme Inhibitors among Heart Failure Patients in Southwest Ethiopia.BioMed research international · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large-scale randomised controlled trials (RCTs) have demonstrated that angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and beta-blockers decrease mortality and hospitalisation in patients with heart failure (HF) associated with a reduced left ventricular ejection fraction. This has led to high prescription rates; however, these drugs are generally prescribed at much lower doses than the doses achieved in the RCTs. A number of strategies have been evaluated to improve medication titration in HF, including forced medication up-titration protocols, point-of-care decision support and extended scope of clinical practice for nurses and pharmacists. Most successful strategies have been multifaceted and have adapted existing multidisciplinary models of care. Furthermore, given the central role of general practitioners in long-term monitoring and care coordination in HF patients, these strategies should engage with primary care to facilitate the transition between the acute and primary healthcare sectors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.