Evidence map›Paper›PMID 28785381›Full record

ArticleWorld journal of stem cells2017

Modifying oxygen tension affects bone marrow stromal cell osteogenesis for regenerative medicine.

Yusuke Inagaki, Manabu Akahane, Takamasa Shimizu, Kazuya Inoue, Takuya Egawa, Tsutomu Kira, Munehiro Ogawa, Kenji Kawate, Yasuhito Tanaka

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of stem cells, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review.International journal of environmental research and public health · 2019
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yusuke InagakiYusuke Inagaki, Takamasa Shimizu, Kazuya Inoue, Takuya Egawa, Tsutomu Kira, Munehiro Ogawa, Yasuhito Tanaka, Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Manabu AkahaneYusuke Inagaki, Takamasa Shimizu, Kazuya Inoue, Takuya Egawa, Tsutomu Kira, Munehiro Ogawa, Yasuhito Tanaka, Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Takamasa ShimizuYusuke Inagaki, Takamasa Shimizu, Kazuya Inoue, Takuya Egawa, Tsutomu Kira, Munehiro Ogawa, Yasuhito Tanaka, Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Kazuya InoueYusuke Inagaki, Takamasa Shimizu, Kazuya Inoue, Takuya Egawa, Tsutomu Kira, Munehiro Ogawa, Yasuhito Tanaka, Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Takuya EgawaYusuke Inagaki, Takamasa Shimizu, Kazuya Inoue, Takuya Egawa, Tsutomu Kira, Munehiro Ogawa, Yasuhito Tanaka, Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Tsutomu KiraYusuke Inagaki, Takamasa Shimizu, Kazuya Inoue, Takuya Egawa, Tsutomu Kira, Munehiro Ogawa, Yasuhito Tanaka, Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Munehiro OgawaYusuke Inagaki, Takamasa Shimizu, Kazuya Inoue, Takuya Egawa, Tsutomu Kira, Munehiro Ogawa, Yasuhito Tanaka, Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Kenji KawateYusuke Inagaki, Takamasa Shimizu, Kazuya Inoue, Takuya Egawa, Tsutomu Kira, Munehiro Ogawa, Yasuhito Tanaka, Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Yasuhito TanakaYusuke Inagaki, Takamasa Shimizu, Kazuya Inoue, Takuya Egawa, Tsutomu Kira, Munehiro Ogawa, Yasuhito Tanaka, Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Nara Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo establish a hypoxic environment for promoting osteogenesis in rat marrow stromal cells (MSCs) using osteogenic matrix cell sheets (OMCSs).

methodsRat MSCs were cultured in osteogenic media under one of four varying oxygen conditions: Normoxia (21% O

resultsIn the NN and HN groups, differentiated, cuboidal-shaped cells were readily observed, along with calcium deposits. In the HN group, the levels of secreted osteocalcin increased rapidly from day 10 as compared with the other groups, and plateaued at day 12 (

conclusionThe results of this study indicate that modifying oxygen tension is an effective method to enhance the osteogenic ability of MSCs used for OMCSs.

Indexed as

HypoxiaMarrow stromal cellsOsteogenesisRegenerative medicineTissue engineering

Identifiers

PMID28785381
PMCPMC5529317
OpenAlexW2736754268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.