ArticleClinical epigenetics2017
Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD.
Article in Clinical epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology.Environmental health : a global access science source · 2025Pooled it
- The association between prenatal famine, DNA methylation and mental disorders: a systematic review and meta-analysis.Clinical epigenetics · 2023Pooled it
- Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Prenatal medication exposure and epigenetic outcomes: a systematic literature review and recommendations for prenatal pharmacoepigenetic studies.Epigenetics · 2022Pooled it
- Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults.Biological psychiatry · 2019Pooled it
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- Vipr2 Gene Expression Is Upregulated in the Nucleus Accumbens of Spontaneous Hypertensive Rats During Early Life.Neuropsychopharmacology reports · 2026Article
- Paracetamol in pregnancy: Navigating clinical uncertainty and avoiding the communication pitfalls of the "measles, mumps, and rubella" - autism controversy: A narrative review.EXCLI journal · 2026Review
- Cohort Profile Update: The Norwegian Mother, Father and Child Cohort (MoBa).International journal of epidemiology · 2025Article
- Maternal immune-mediated conditions and ADHD risk in offspring.BMC medicine · 2025Article
- Associations of maternal blood biomarkers of prenatal APAP exposure with placental gene expression and child attention deficit hyperactivity disorder.Nature. Mental health · 2025Article
- A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison.Nature. Mental health · 2025Article
- Review
- Prenatal Acetaminophen Exposure and its Associated Risk for Attention Deficit Hyperactivity Disorder.Health psychology research · 2024Article
- Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamol.iScience · 2023Article
- Association between acetaminophen metabolites and CYP2E1 DNA methylation level in neonate cord blood in the Boston Birth Cohort.Clinical epigenetics · 2023Article
- Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes.Antibiotics (Basel, Switzerland) · 2023Article
- Paracetamol use in pregnancy: Not as safe as we may think?Acta obstetricia et gynecologica Scandinavica · 2023Article
- Effects of prenatal exposure to (es)citalopram and maternal depression during pregnancy on DNA methylation and child neurodevelopment.Translational psychiatry · 2023Article
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundEpidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder (ADHD). The mechanism by which paracetamol may modulate the increased risk of developing ADHD is currently unknown. We have conducted an epigenome-wide association study (
resultsAnalyses identified significant differences in DNA methylation (
conclusionsThese initial findings suggest that in individuals susceptible to ADHD, prenatal long-term exposure to paracetamol is associated with DNA methylation differences compared to controls.
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Registered trials
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